Tests Shiatsu massage for symptoms in people with cardiac amyloidosis
Tests targeted Shiatsu massage to ease symptoms in adults with severe cardiac amyloidosis.
Plain-language title generated from the registry record
Registry title: Amylo-Shiatsu-Acute-Chronic: Effects of Shiatsu on Symptoms and Quality of Life of Amyloidosis Patients
Key facts
- Where
- Créteil, FranceSee the site
Where in France
- Assistance Publique - Hopitaux de Paris - CHU Henri MondorCréteil, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT06197165
- Record updated
- 15 January 2026
- Original description
The objective of this study is to assess the beneficial effects of three targeted Shiatsu sessions compared to "comfort" Shiatsu on symptoms in patients with severe cardiac amyloidosis. Specifically, the study aims to evaluate the short-term impact of a targeted Shiatsu session on neuro-cardiovascular physiological parameters and symptoms in patients with cardiac amyloidosis, in comparison to comfort Shiatsu and no Shiatsu. Additionally, the study will investigate the effects of three targeted Shiatsu sessions versus "comfort" Shiatsu and no Shiatsu on various symptoms (fatigue, sleep disturbances, pain, anxiety, depression, dyspnea, digestive disorders, nausea) and quality of life in cardiac amyloidosis patients with severe symptoms. Patient satisfaction with Shiatsu will also be evaluated, alongside an assessment of the tolerance to Shiatsu.Read full original descriptionShow less
Amylo-Shiatsu-Acute-Chronic: Effects of Shiatsu on Symptoms and Quality of Life of Amyloidosis Patients
The objective of this study is to assess the beneficial effects of three targeted Shiatsu sessions compared to "comfort" Shiatsu on symptoms in patients with severe cardiac amyloidosis. Specifically, the study aims to evaluate the short-term impact of a targeted Shiatsu session on neuro-cardiovascular physiological parameters and symptoms in patients with cardiac amyloidosis, in comparison to comfort Shiatsu and no Shiatsu. Additionally, the study will investigate the effects of three targeted Shiatsu sessions versus "comfort" Shiatsu and no Shiatsu on various symptoms (fatigue, sleep disturbances, pain, anxiety, depression, dyspnea, digestive disorders, nausea) and quality of life in cardiac amyloidosis patients with severe symptoms. Patient satisfaction with Shiatsu will also be evaluated, alongside an assessment of the tolerance to Shiatsu.
Inclusion: Age ≥ 18 years ; Patient with :; Transthyretin of genetic origin (TTR) ; Transthyretin of non-mutated origin (WT) ; Light Chain (AL); Membership of a social security scheme, beneficiary or beneficiary's beneficiary (excluding AME); Written patient consent; Score greater than or equal to 3 on the EESE-R questionnaire (Edmonton Symptom Evaluation Scale-Revised), for at least 1 symptom among: dyspnea, digestive disorders, nausea, pain, anxiety, depression (Shiatsu and non-Shiatsu groups); Score global à l'EESE-R supérieur ou égal à 10 (groupes Shiatsu et sans shiatsu).
Exclusion: Patients who have already received Shiatsu treatment; Participating in another interventional study, or within the exclusion period of a previous study, if applicable; Patients with orthostatic hypotension; Patients with bullous amyloidosis (fragile skin); Patient with insufficient autonomy to maintain sitting position; Patient with insufficient autonomy to move from home to hospital; Known pregnancy or breast-feeding; Patient under known guardianship at the time of inclusion; Patient under AME.