NCT06203158Completed
Intestinal Epithelial Fucosylation Affects the Efficacy of Ustekinumab in Crohn's Disease
Source: ClinicalTrials.gov · Last updated 8 Mar 2024
Brief summary (registry, in English)
The loss of response rate of ustekinumab(UST) is high, and the specific mechanism has not yet been elucidated. Molecular markers that can accurately predict the efficacy of UST are urgently needed to provide theoretical basis for guiding individualized treatment. Therefore, this study intends to explore the impact of intestinal epithelial fucosylation levels on the efficacy of UST in patients with Crohn's disease(CD), aiming to provide predictable molecular markers for UST to accurately treat CD.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 50 (actual)
- First submitted
- 20 Dec 2023
- Start date
- Dec 2023
- Primary completion date
- Feb 2024
- Lead sponsor
- Second Affiliated Hospital of Wenzhou Medical University
- Diseases
- Crohn's disease
- NCT number
- NCT06203158
What you commit to
- Study type: Observational
- Participants enrolled: 50
- From Dec 2023 to the primary completion date, Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Hypersensitivity to any component of ustekinumab
- Combined with diseases such as RA, diabetes, systemic lupus erythematosus, intestinal tuberculosis, ischemic enteritis, radiation enteritis and tumors
Other
- Pregnancy
- Cognitive or developmental disabilities prevent you from completing this study
Who the study is looking for
- Diagnosed with moderate to severe Crohn's disease
- Receiving treatment with ustekinumab
- Received colonoscopy and collected intestinal tissue samples before and after treatment
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Second Affiliated Hospital of Wenzhou Medical University Coordinator of this site? Confirm its status | Wenzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.