Eating within an 8-hour window for women with ovarian syndrome and excess weight
Tests timed eating plus healthy eating advice in overweight women with PMOS.
Plain-language title generated from the registry record
Registry title: Time-Restricted Eating as a Dietary Intervention for Polyendocrine Metabolic Ovarian Syndrome (PMOS): Protocol for a Randomized Controlled Trial
Key facts
- Where
- Poznan, PolandSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women aged 18-40 with polyendocrine metabolic ovarian syndrome (PMOS) and overweight or obesity. It tests an 8-hour eating window plus healthy eating advice over 8 weeks.
- Age
- 18-40 years
- Sex
- Women only
- Disease stage
- A doctor-confirmed diagnosis of PMOS (also known as PCOS), set by the 2023 international guideline, with a BMI of 25-40 kg/m².
- Earlier treatment
- Within the last 3 months, no medicines or supplements that affect sugar or fat metabolism, body weight or reproductive hormones. This includes hormonal contraceptives, metformin, inositols, probiotics and prebiotics. No antibiotics in the last 3 months.
Main reasons for not taking part
- Smoking in the last 3 months, or alcohol over 100 g per week
- Body weight change of more than 5% in the last 3 months
- Current or past eating disorder
- Pregnancy or breastfeeding
- Shift work or night work, or type 1 or type 2 diabetes
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT06204965, who can take part
Where in Poland
- Poznań University of Life SciencesPoznan, PolandContact: Joanna Bajerska, Assoc. Prof.No longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Joanna Bajerska
- Trial code
- NCT06204965
- Record updated
- 16 October 2026
- Original description
Polyendocrine Metabolic Ovarian Syndrome (PMOS), previously known as PCOS, is a common endocrine disorder associated with metabolic, reproductive, and hormonal abnormalities. Growing evidence suggests that time-restricted eating (TRE) may improve body weight regulation, insulin sensitivity, hormonal balance, and menstrual function in women with PMOS. However, the mechanisms underlying these benefits remain unclear, particularly regarding the role of the gut microbiota and neurohormonal pathways.Read full original descriptionShow less
Time-Restricted Eating as a Dietary Intervention for Polyendocrine Metabolic Ovarian Syndrome (PMOS): Protocol for a Randomized Controlled Trial
Polyendocrine Metabolic Ovarian Syndrome (PMOS), previously known as PCOS, is a common endocrine disorder associated with metabolic, reproductive, and hormonal abnormalities. Growing evidence suggests that time-restricted eating (TRE) may improve body weight regulation, insulin sensitivity, hormonal balance, and menstrual function in women with PMOS. However, the mechanisms underlying these benefits remain unclear, particularly regarding the role of the gut microbiota and neurohormonal pathways.
This randomized controlled trial will investigate whether combining an 8-hour TRE regimen with Healthy Eating Plate dietary recommendations provides greater benefits than dietary recommendations alone. Women aged 18-40 years with PMOS and overweight or obesity will participate in an 8-week intervention. The study will assess changes in gut microbiota composition, microbial metabolites, metabolic health, hormonal profile, neurohormonal markers, and body composition.
The study is expected to provide novel insights into the interactions between meal timing, gut microbiota, neuroendocrine regulation, and clinical manifestations of PMOS, contributing to the development of more effective and sustainable dietary strategies for this condition.
Eligible participants will be women aged 18-40 years with a BMI of 25-40 kg/m² and a physician-established diagnosis of PMOS established according to the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome . The exclusion criteria, assessed at the screening visit by structured interview and review of medical documentation, will be:; use within the previous 3 months of medications or supplements affecting carbohydrate or lipid metabolism, body weight, reproductive hormones including hormonal contraceptives, antiandrogens, glucocorticoids, weight-loss medications, insulin-sensitizing agents (e.g., metformin, inositols), probiotic or prebiotic supplements; antibiotic treatment within the previous 3 months; smoking within the previous 3 months or alcohol consumption >100 g/week; participation in competitive sports or structured athletic training; significant body weight fluctuations (>5%) during the 3 months preceding study enrollment; current or past diagnosis of anorexia nervosa, bulimia nervosa, binge eating disorder, or other clinically significant eating disorders; pregnancy or breastfeeding; shift work or night work; diagnosed type 1 or type 2 diabetes.