Tests a vegetarian diet's effect on immunity after heart attack
Tests a vegetarian diet's effect on immune function in adults after a recent heart attack.
Plain-language title generated from the registry record
Registry title: Vegetarian Diet and Innate Immunity in Patients With Myocardial Infarction and in Healthy Volunteers (FRESH-MI Study)
Key facts
- Where
- Nijmegen, NetherlandsSee the site
Where in Netherlands
- RadboudumcNijmegen, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Radboud University Medical Center
- Trial code
- NCT06209723
- Record updated
- 14 August 2026
- Original description
The goal of this clinical trial is to assess the effect of a vegetarian diet on innate immunity of patients with a recent acute myocardial infarction and healthy participants. Also, we will assess the willingness to adapt a more vegetarian eating habit. Study subjects will follow a vegetarian diet for five weeks, whereafter a stabilisation period of six weeks will follow. Then, participants will follow to the other dietary intervention for five weeks. Blood will be drawn at given time points to analyse inflammatory parameters.Read full original descriptionShow less
Effect of a Vegetarian Diet on Innate Immunity in Patients With Myocardial Infarction and in Healthy Volunteers (FRESH-MI Study)
The goal of this clinical trial is to assess the effect of a vegetarian diet on innate immunity of patients with a recent acute myocardial infarction and healthy participants. Also, we will assess the willingness to adapt a more vegetarian eating habit. Study subjects will follow a vegetarian diet for five weeks, whereafter a stabilisation period of six weeks will follow. Then, participants will follow to the other dietary intervention for five weeks. Blood will be drawn at given time points to analyse inflammatory parameters.
Inclusion: Acute myocardial infarction (STEMI/NSTEMI) with a clear culprit lesion on angiography and successful primary percutaneous coronary intervention (PCI) <1 week before randomisation; Body mass index between 18.5 and 35 kg/m2; Written informed consent; Body mass index between 18.5 and 35 kg/m2; Written informed consent.
Exclusion: Previous myocardial infarction; Use of immunomodulatory drugs; Vaccination less than one month before start of intervention; Clinically significant infections within 1 months prior to start of intervention (defined as fever >38.5 degrees Celsius); Use of lipid lowering therapy; Diabetes Mellitus; Medical history of any disease associated with immune deficiency (either congenital or acquired, including chemotherapy, chronic steroid use, organ transplant); Active malignant haematological disease; Known eating disorder (e.g., Anorexia nervosa, Bulimia nervosa); Already on a vegetarian or vegan diet.