Tests laser acupuncture as add-on care for chronic migraine
Tests laser acupuncture alongside usual medicines in adults with chronic migraine.
Plain-language title generated from the registry record
Registry title: Laser Acupuncture for Chronic Migraine
Key facts
- Where
- Taichung, TaiwanSee the site
Where in Taiwan
- Taichung Veterans General HospitalTaichung, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Taichung Veterans General Hospital
- Trial code
- NCT06219694
- Record updated
- 20 November 2025
- Original description
A single-blind randomized controlled trial was conducted from October 2024 to May 2025. Chronic migraine patients were randomly assigned in a 1:1 ratio to receive either Laser acupuncture or sham treatment. The co-primary outcomes were changes in monthly migraine days (MMD) and acute headache medications usage days per month from baseline, and Hospital Anxiety and Depression Scale (HADS), and Beck's Depression Inventory(BDI) evaluation. Evaluations were taken at baseline and each follow-up point.Read full original descriptionShow less
Enhancing Chronic Migraine Preventive Therapy: Laser Acupuncture as an Add-On Treatment for Patients With Unsatisfactory Pharmacological Effect, a Pilot Randomized Controlled Trial
A single-blind randomized controlled trial was conducted from October 2024 to May 2025. Chronic migraine patients were randomly assigned in a 1:1 ratio to receive either Laser acupuncture or sham treatment. The co-primary outcomes were changes in monthly migraine days (MMD) and acute headache medications usage days per month from baseline, and Hospital Anxiety and Depression Scale (HADS), and Beck's Depression Inventory(BDI) evaluation. Evaluations were taken at baseline and each follow-up point.
After >6 months follow up as washing out time, the sham group received complementary laser acupuncture treatment and follow up for another 3 months, compared the Headache related parameters (onset, duration, pain scale, current medication for headache, menstrual cycle).
Inclusion: patients aged above 20 years old and had CM managed pharmacologically, including preventive and/or acute migraine medications, and in addition, those who had refused preventive agent despite recommendation of the neurologist; patients who had unsatisfactory effect of current pharmacological treatments, defined as they self-reported; patients who had a minimum of one-year history of migraine with or without aura.
Exclusion: patients who had received another LA therapy or traditional acupuncture at baseline; cognitive or psychological impairment interfering with the participant's ability to receive LA protocol and describe symptoms; migraine onset after the age of 50; patients with missing data at baseline or during the follow-up period.