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Taking people in United StatesNo phase

Short-term And Longer-term Cognitive Impact Of Neurochecks

Key facts

Who runs it
University of California, San Diego
Where
San Diego, United StatesSee the site
Trial code
Status
Recruiting
People taking part
120 people, planned
Started
8 Jul 2024
Expected to end
31 Oct 2029
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Frequency of neurochecks
Record updated
10 September 2025

Who can take part

Age
18 years to 100 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Adult patients (age >18 years) with spontaneous acute <45cc in volume with radiographic and clinical stability for ≥6 hours following admission to the ICU. These criteria are based on the literature and experience of the investigative team
  • Additional intraventricular hemorrhage (with or without external ventricular drain) is allowable
  • Only first admission to the NeuroICU during the hospitalization will be eligible
  • any patient included in part 1 alive at 6 months post-discharge

Who cannot take part

  • Patients with unstable intracranial bleeding
  • Patients with known history of intracranial neurological injury
  • Pre-existing cognitive impairment (known or highly suspected based on family-provided history, Activities of Daily Living Questionnaire)
  • Pre-existing diagnosed sleep disorder
  • Death expected within 30 days or other terminal illness
  • Comatose or heavily sedated
  • ICH score >4 (equivalent to mortality risk >72%)
  • Pregnancy
  • Incarcerated
  • Non-English or non-Spanish speaking

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 100 years old?

Where in United States

  • UC San Diego HealthSan Diego, United StatesContact: Jamie N LaBuzettaTaking people

About the trial

What the trial wants to find out

The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent serial neurological examinations ("neurochecks") in an effort to monitor patients for neurological deterioration following brain injury. Many neurocritical patients are older and/or cognitively fragile, and delirium is common. Although ICU delirium is multifaceted, frequent neurochecks may represent a modifiable risk factor if the investigators can better understand the risks and benefits of various neurocheck frequencies. This project will randomize patients with acute spontaneous intracerebral hemorrhage (ICH) to either hourly (Q1) or every-other-hour (Q2) neurochecks and evaluate the impact of neurocheck frequency on delirium. Second, longer-term cognitive outcomes will be investigated in patients with ICH randomized to Q1 versus Q2 neurochecks with the goal of identifying whether hourly neurochecks increase the risk for dementia.

The 2 groups in the trial

  • Hourly NeurochecksExisting treatment, for comparison

    Patients will be awakened hourly for their examinations

    Treatment: Frequency of neurochecks

  • Every-Other-Hour NeurochecksTreatment being tested

    Patients will be awakened every other hour for their examinations

    Treatment: Frequency of neurochecks

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Short-term And Longer-term Cognitive Impact Of Hourly Neurochecks In Acute Brain Injury
Fit questions
Built from NCT06219889, who can take part
Record updated
10 September 2025