Gastroparesis as an Early Sign of Sepsis
Key facts
- Who runs it
- Meir Medical Center
- Where
- Israel1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 260 people enrolled
- Started
- 1 Jun 2024
- Ended
- 1 May 2025
- Type of study
- Observational, 2 groups
- Treatments tested
- presence of gastroparesis as an early sign for sepsis (bacteremia)- measurement of gastric residual volume
- Record updated
- 13 May 2025
Who can take part
- Age
- 18 years to 99 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- -
Who cannot take part
- -
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Upper gastrointestinal tract disorders, such as gastroparesis, are common in critically ill patients in the ICU, estimated at 60%. Gastroparesis symptoms include nausea, vomiting and abdominal pain. Risk factors for the development of gastroparesis include diabetes, surgical injury to the vagus nerve (such as certain types of bariatric surgery, and in the past - surgeries for patients who suffered from peptic ulcer), use of drugs that inhibit the activity of the digestive system such as opiates, anticholinergic drugs, sepsis, as well as being bedridden and inactive - are all common conditions in critically ill patients.
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There are different definitions for gastroparesis. One of the accepted definitions refers to gastric residual volume (GRV) over 200 ml at one measurement. Gastroparesis is found in some studies to be associated with increased morbidity and mortality in critically ill patients. As mentioned above, it is known that sepsis is a risk factor for gastroparesis. According to our experience based on treatment of a large number of septic patients, we have the impression that often gastroparesis is an early sign for the development of sepsis. We did not find any studies that tested this hypothesis.
In this study we would like to investigate whether the development of gastroparesis in critical patients in intensive care can be a predictive sign for the development of sepsis.
The 2 groups in the trial
- patients with ICU-acquired bacteremia
Treatment: presence of gastroparesis as an early sign for sepsis (bacteremia)- measurement of gastric residual volume
- patients without ICU-acquired bacteremia
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 13 May 2025