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Compares two devices in glaucoma patients having cataract surgery

Compares ELIOS with a competitor device during cataract surgery in people with open-angle glaucoma.

Key facts

Who runs it
Elios Vision, Inc.
Where
East Grinstead, Edinburgh, Guildford, London, and Manchester, United KingdomSee the 5 sitesAlso in 5 other countries, 11 sites
Trial code
Registry title
Comparative Effectiveness and Safety of ELIOS in Patients With Open-Angle Glaucoma Undergoing Cataract Surgery
Status
Recruiting
People taking part
194 people, planned
Started
5 Dec 2023
Expected to end
Dec 2028
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • ELIOS
  • Competitor Device
Record updated
17 June 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with mild to moderate open-angle type glaucoma who also have a cataract that needs surgery.

Age
40 years or older
Sex
Men and women can join.
Disease stage
Mild to moderate primary open-angle glaucoma, pseudoexfoliation glaucoma or pigmentary glaucoma, plus a cataract that affects vision and can be treated with phacoemulsification.
Earlier treatment
No earlier glaucoma surgery, eye surgery or eye laser treatment, except selective laser trabeculoplasty (SLT) done at least 6 months before the screening visit.

Main reasons for not taking part

  • Any form of angle closure glaucoma
  • Secondary glaucoma (for example after injury, or linked to new blood vessels, uveitis, lens, steroids or other causes)
  • Congenital or developmental glaucoma
  • Earlier glaucoma surgery, other eye surgery or eye laser treatment (SLT more than 6 months before screening is allowed)

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Male or female subjects
  • 40 years old or older
  • Diagnosis of mild to moderate primary open-angle glaucoma, pseudoexfoliation glaucoma or pigmentary glaucoma:
  • Visually significant cataract eligible for phacoemulsification

Who cannot take part

  • Prior incisional glaucoma surgery, intraocular surgery or ocular laser treatment of any type with the exception of selective laser trabeculoplasty (SLT) occurring a minimum of 6 months prior to the Screening visit
  • Secondary glaucoma, including traumatic, neovascular, uveitic, lens-induced, steroid-induced, angle-recession, glaucoma associated with vascular disorders, and glaucoma associated with increased episcleral venous pressure
  • All forms of angle closure glaucoma
  • Congenital or developmental glaucoma

Where in United Kingdom

Also in 5 other countries, 11 sites

  • East GrinsteadHospital not named in the registryContact: Cameron HudsonTaking people
  • EdinburghHospital not named in the registryContact: Cameron HudsonTaking people
  • GuildfordHospital not named in the registryContact: Cameron HudsonTaking people
  • LondonHospital not named in the registryContact: Cameron HudsonTaking people
  • ManchesterHospital not named in the registryContact: Cameron HudsonTaking people

About the trial

What the trial wants to find out

The primary study objective is to compare the effectiveness of the combination of phacoemulsification with intraocular lens implant with ELIOS or competitor device in reducing IOP at 12 months postoperatively.

The 2 groups in the trial

  • Arm 1Existing treatment, for comparison

    ELIOS

    Treatment: ELIOS

  • Arm 2Existing treatment, for comparison

    Competitor Device

    Treatment: Competitor Device

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Prospective, Multicenter, Randomized Clinical Trial to Evaluate the Safety and Effectiveness of ELIOS vs Competitor in Patients With Open-Angle Glaucoma Undergoing Cataract Surgery
Plain-language title
Compares two devices in glaucoma patients having cataract surgeryGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
17 June 2026