Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Key facts
- Who runs it
- Karolinska Institutet
- Where
- Sweden1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 90 people, planned
- Started
- 21 Feb 2024
- Planned end
- 1 Mar 2026
- Type of study
- Observational
- Treatments tested
- Mitral valve surgery
- Record updated
- 11 September 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Age 18 and over
- Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care
Who cannot take part
- Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
- Co-existing moderate or severe aortic valve disease
- Congenital heart disease
- Non-incidental or symptomatic coronary artery disease
- Uncontrolled atrial fibrillation (resting heart rate > 100/min)
- Secondary mitral regurgitation
- Inherited or acquired cardiomyopathy
- Pregnancy
- Unable to undergo CMR
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Study objectives:
Read full original descriptionShow less
* To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP
Study design:
-Prospective explorative observational study
Study population:
-90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery
The group in the trial
- Arrhythmogenic mitral valve prolapse versus non-arrhythmogenic mitral valve prolapse
Surgical repair or replacement of the mitral valve due to significant mitral regurgitation according to standard of care.
Treatment: Mitral valve surgery
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Mechanisms and Outcomes in Patients With Arrhythmic Mitral Valve Prolapse Undergoing Mitral Valve Surgery
- Record updated
- 11 September 2025