Studying Patients in Intensive Care for a Severe COPD Flare-Up
Observes adults in intensive care for severe flare-ups of COPD, a lung disease.
Plain-language title generated from the registry record
Registry title: Characteristics and Outcomes of Patients Admitted to ICU for a Severe Acute Exacerbation of COPD.
Key facts
- Where
- Grenoble, Le Chesnay, Le Mans, and Rennes, FranceSee the 4 sites
Where in France
- CHU de GrenobleGrenoble, FranceTaking people
- Centre Hospitalier de VersaillesLe Chesnay, FranceTaking people
- CH Le MansLe Mans, FranceTaking people
- CHU RennesRennes, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alexis FERRE
- Trial code
- NCT06257329
- Record updated
- 27 October 2026
- Original description
The objective of this prospective observational study is to describe the epidemiological, clinical and biological characteristics of patients admitted in ICU for a severe acute exacerbation of COPD, and to assess the different treatment received received, to evaluate the prognosis with short, mid and long term ( 1 year) mortality and the factors associated with survival.Read full original descriptionShow less
Epidemiological, Clinical and Biological Characteristics, and Therapeutic Management of ICU Patients With Severe Acute Exacerbation of COPD. Evaluation of Prognosis and Factors Associated With Survival.
The objective of this prospective observational study is to describe the epidemiological, clinical and biological characteristics of patients admitted in ICU for a severe acute exacerbation of COPD, and to assess the different treatment received received, to evaluate the prognosis with short, mid and long term ( 1 year) mortality and the factors associated with survival.
Inclusion: Age ≥ 40 years old; COPD documented or strongly suspected; Chronic respiratory symptoms (dyspnoea, cough and/or sputum); Exposure to a known risk factor for COPD (such as tobacco smoke); If available, respiratory function tests showing non- or partially reversible obstructive syndrom (post-bronchodilator ratio FEV1/CV < 0.7); Severe acute exacerbation, defined as a worsening of the patient's usual respiratory symptoms with signs of acute respiratory distress (polypnoea ≥ 30 cycles.min-1 or use of accessory respiratory muscles) and/or hypercapnic acidosis (with PaCO2 ≥ 45 mmHg and pH ≤ 7.35); Admission to an ICU, a step-up unit or a respiratory care unit.
Exclusion: Known asthma (according to the criteria of the international "Global initiative for asthma" guidelines); Patient refusal to participate (information note, application for non-opposition).