Monitoring or surgery for small low-risk papillary thyroid cancer
Compares watching small, low-risk thyroid cancers closely with immediate surgery in adults.
Plain-language title generated from the registry record
Registry title: Active Surveillance for Low-risk Papillary Thyroid Carcinoma
Key facts
- Where
- Goyang-si, Seongnam, and Seoul, South KoreaSee the 4 sites
Where in South Korea
- National Cancer CenterGoyang-si, South KoreaNo longer taking part
- Seoul National University Bundang HospitalSeongnam, South KoreaNo longer taking part
- Seoul National University HospitalSeoul, South KoreaNo longer taking part
- SMC-SNU Boramae Medical CenterSeoul, South KoreaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Center, Korea
- Trial code
- NCT06261190
- Record updated
- 11 May 2025
- Original description
This is a multi-center, non-randomized, prospective observational cohort study aimed at establishing a cohort of low-risk papillary thyroid cancer patients with a maximum tumor diameter of 1.5 cm or less, consisting of an active surveillance group and an immediate surgery group.Read full original descriptionShow less
Study Protocol of Extended Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Carcinoma (MAeSTro-EXP)
This is a multi-center, non-randomized, prospective observational cohort study aimed at establishing a cohort of low-risk papillary thyroid cancer patients with a maximum tumor diameter of 1.5 cm or less, consisting of an active surveillance group and an immediate surgery group.
Inclusion: subjects over 18 years old with a thyroid nodule of ≤ 1.5 cm in maximum diameter and a Bethesda category V or VI diagnosis on cytopathology; subjects without high-risk features, including lymph node (LN) metastasis, distant metastasis, signs or symptoms of invasion to the recurrent laryngeal nerve or trachea, Poorly differentiated cancer or variant with a poor prognosis, such as the tall cell, diffuse sclerosing, columnar cell, or solid variants.
Exclusion: subjects who are unable or unwilling to attend regular follow-ups; subjects with a diagnosis of benign, atypia of undetermined significance, suspicious for follicular neoplasm, or follicular neoplasm (Bethesda category II, III, or IV) based on Fine needle aspiration or, or benign, indeterminate by core needle biopsy.