Tests several drug treatments for acute myeloid leukemia that has returned or not responded
Compares several drug treatments in people with returned or unresponsive acute myeloid leukemia.
Plain-language title generated from the registry record
Registry title: Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia
Key facts
- Where
- Tianjin, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people with acute myeloid leukemia (AML) that did not respond to treatment or came back. It compares different treatment plans.
- Age
- No age limit. Under 18, a legal guardian signs the consent.
- Sex
- All sexes can join.
- Disease stage
- AML that is refractory (did not respond) or relapsed (came back). The relapse must be seen under the microscope, not only in molecular tests. Acute promyelocytic leukemia and leukemia only outside the bone marrow are left out.
- Earlier treatment
- Not stated as a general rule. Some treatment groups depend on whether the person had venetoclax in the last 3 months.
- Biomarker or test result
- Some treatment groups need an IDH1 gene change or a FLT3 gene change. Other groups are for people without these changes.
Main reasons for not taking part
- Acute promyelocytic leukemia
- Leukemia only outside the bone marrow
- Relapse seen only in molecular tests
- Another cancer in a different organ that needs treatment
- Anyone the researchers judge not fit to join
Read by machine on 11 November 2026.
Where in China
- Blood HospitalTianjin, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institute of Hematology & Blood Diseases Hospital, China
- Trial code
- NCT06265545
- Record updated
- 7 August 2026
- Original description
To study the optimal therapeutic strategies for salvage treatment of refractory/relapsed AML, and to clarify the effectiveness and safety of various salvage treatment options. A prospective, multicenter, platform-type study was conducted to explore the overall response rate, tolerability, and survival of patients with R/R AML with different treatment regimens.Read full original descriptionShow less
Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia
To study the optimal therapeutic strategies for salvage treatment of refractory/relapsed AML, and to clarify the effectiveness and safety of various salvage treatment options. A prospective, multicenter, platform-type study was conducted to explore the overall response rate, tolerability, and survival of patients with R/R AML with different treatment regimens.
Inclusion: 1. Patients with acute myeloid leukemia (except for acute promyelocytic leukemia) diagnosed by bone marrow cell morphology, immunology and genetics above are classified according to the French-British-American Collaboration diagnostic criteria (FAB criteria) and the World Health Organization diagnostic criteria (WHO2016 criteria); Meet criteria for refractory/recurrent AML (except APL). The recurrence was morphological recurrence, excluding molecular recurrence. Except for simple extramedullary leukemia; Age and gender are not limited. 4. Informed consent must be signed before the start of the study procedure, and the informed consent must be signed by the patient himself or his immediate family if he is 18 years old and above; For young patients under the age of 18, the legal guardian shall sign the informed consent. Considering the patient's condition, if the patient's signature is not conducive to the treatment of the condition, the informed consent shall be signed by the legal guardian or the patient's immediate family.
Exclusion: Concurrent malignant tumors of other organs (patients requiring treatment); Participants considered unsuitable for inclusion by the researchers.