Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)
Key facts
- Where
- Rochester, United StatesSee the 2 sites
Where in United States
- Mayo ClinicRochester, United StatesNo longer taking part
- Mayo Clinic in RochesterRochester, United StatesNo longer taking part
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT06268288
- Record updated
- 31 October 2025
- Original description
The purpose of this study is to determine if nVNS will decrease autonomic symptom intensity (COMPASS-31 and Child Functional Disability Inventory) in adolescent patients with postural orthostatic tachycardia syndrome (POTS) in comparison to standard recovery STEPS management.Read full original descriptionShow less
Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)
The purpose of this study is to determine if nVNS will decrease autonomic symptom intensity (COMPASS-31 and Child Functional Disability Inventory) in adolescent patients with postural orthostatic tachycardia syndrome (POTS) in comparison to standard recovery STEPS management.
Inclusion: Patient's age 12-19 years of age; Newly diagnosed POTS at Mayo Clinic in Rochester; Head up tilt table test results in a heart rate increase of 40 or more bpm; Consent is able to be obtained appropriately per age.
Exclusion: Use of medications other than midodrine or metoprolol; Patients receiving hormonal therapy other than birth control; Prior neck surgery; Metallic implant present; Cardiac disorder; Presence of an eating disorder; POTS patients with orthostatic hypotension; POTS patients with vasovagal syncope; Inability to independently utilize the GammaCore device; Inability to independently complete surveys or patient logs; Pregnancy; Use of a feeding tube.