Under construction – not a live service
Sign in
Not yet taking people in GermanyNo phase

Comparing Two Ways of Giving Adenosine to Check Heart Small Vessel Function

Compares adenosine given into a vein or the heart artery in microvascular coronary artery disease.

Key facts

Who runs it
Johannes Gutenberg University Mainz
Where
Mainz, GermanySee the site
Trial code
Registry title
Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment
Status
Not yet recruiting
People taking part
40 people, planned
Starts
2 Mar 2027
Expected to end
31 Aug 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • microvascular function assessment
Record updated
8 October 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with chronic coronary syndrome who are already having a heart catheter test and a check of the tiny heart blood vessels.

Age
Over 18 years
Sex
All sexes can join
Disease stage
Chronic coronary syndrome, including people whose symptoms are similar to angina (chest pain from the heart)

Main reasons for not taking part

  • Bronchial asthma or COPD
  • Second or third degree atrioventricular block (a heart rhythm block) without a pacemaker
  • Previous bypass surgery (CABG) with open grafts to the left anterior descending artery
  • Narrowing of a main heart artery (FFR below 0.80 with a focal stenosis) in the left anterior descending area
  • Unable to give informed consent

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Chronic coronary syndrome (including patients with anginal equivalents)
  • Indication to cardiac catheterization
  • Indication to the assessment of microvascular function (note: patients will be asked for participation and consented prior to the first measurement of microvascular function, which will be conducted as per clinical indication)
  • Willingness to participate and ability to understand, read and sign the informed consent
  • Age>18 years

Who cannot take part

  • Secondary or tertiary atrioventricular block without prior pacemaker implantation
  • Previous CABG (coronary artery bypass graft) with patent grafts to the left anterior descending coronary
  • Bronchial asthma, COPD (chronic obstructive pulmonary disease)
  • Epicardial coronary disease (FFR <0.80 with evidence of a focal stenosis) in the left anterior descending territory
  • Age <18 years
  • Inability to provide informed consent

Where in Germany

  • Center of Cardiology, Cardiology I, university hospital MainzMainz, GermanyContact: Tommaso Gori, MD, PhDNo longer taking part

About the trial

What the trial wants to find out

The aim of this study is to investigate the agreement and reproducibility between intravenous and intracoronary adenosine administration during invasive assessment of microvascular function.

Read full original descriptionShow less

Goals of this study are:

1. Agreement and reproducibility between intravenous and intracoronary adenosine administration in the IMR (Index of microvascular resistance) value. 2. Agreement and reproducibility of FFR(fractional flow reserve), CFR (coronary flow reserve), MRR (microvascular resistance reserve), RRR (resistive reserve ratio) and reproducibility of each of these as compared with CFRabs (absolute coronary flow). 3. Time required for IMR measurements

The 2 groups in the trial

  • Intravenous AdenosineExisting treatment, for comparison

    Invasive microvascular function assessment will be conducted by administering intravenous hyperemic agent adenosine.

    Treatment: microvascular function assessment

  • Intracoronary AdenosineTreatment being tested

    Invasive microvascular function assessment will be conducted by administering intracoronary hyperemic agent adenosine.

    Treatment: microvascular function assessment

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Single-centric, ProspectivE, Randomized Controlled Study Comparing Two Administration Pathways for Adenosine During Invasive Assessment of Microvascular Function in Patients With ANOCA.
Plain-language title
Comparing Two Ways of Giving Adenosine to Check Heart Small Vessel FunctionGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
8 October 2024