Tests colon cancer tumor tissue grown in zebrafish embryos
Implants patients' colon tumor tissue into zebrafish embryos to test chemotherapy response.
Key facts
- Who runs it
- University Hospital, Linkoeping
- Where
- Linköping, SwedenSee the site
- Trial code
- Registry title
- Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer Using Zebra Fish Avatars
- Status
- Recruiting
- Phase
- Phase 1/2
- People taking part
- 300 people, planned
- Started
- 10 Jan 2022
- Expected to end
- 31 Dec 2028
- Type of study
- Interventional
- Treatments tested
- Chemotherapy drug
- Record updated
- 21 February 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with colon cancer who are planned for surgery to remove the colon tumour. A piece of the tumour is placed in zebrafish embryos to study how it grows and responds to treatment.
- Age
- 18 years and older
- Sex
- All sexes can join
- Disease stage
- Colon cancer planned for radical colon resection (surgery to remove the tumour)
Main reasons for not taking part
- People who are not willing to take part
- People who have not signed informed consent
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- Colon cancer planned for radical colon resection signed informed consent
Who cannot take part
- Not willing to participate
Where in Sweden
- Per SandströmLinköping, SwedenContact: Per Sandström, ProfTaking people
About the trial
What the trial wants to find out
In order to improve and individualize cancer treatment personalized treatments developed much further. Colon cancer is treated with surgery and thereafter adjuvant oncological treatment. The selection of chemotherapy is today mainly done according to best guess. Today only a small fraction of oncological treatment may be known to be effective in a person before treatment start, most often it is trial and error. A fast reliable system for looking at response to different treatments in each unique patient is much needed and would, if successful, completely change the way we give oncological treatment today. This system would also be possible to use to evaluate new treatments and if successful, implement in the clinical setting. In this project we will implant a part of the patient's tumour tissue into a zebrafish embryo and evaluate tumour growth and frequency of metastatic disease as well as response to given oncological treatment.
Read full original descriptionShow less
2.2 Objective: The objective of this project is to explore the usefulness of zebrafish (Danio Rerio) embryo models to determine tumor biology and treatment response in colon cancer. An overarching goal would be, before start of any oncological treatment in a patient, to have evaluated the response of oncological treatment in the zebrafish avatar and only treat with a combination of drugs known to have effect against the patient's own tumour.
2.3 Study design: This protocol describes a series of prospective studies in different cohorts of patients with colon cancer to investigate the applicability of zebrafish embryo models. The common denominator of the sub-studies is prospective collection of tumor tissue implanted in zebrafish embryos in order to evaluate if the model is robust enough for growing colon cancer tissue and evaluate growth pattern and response to chemotherapy. This study protocol is designed according to and in adherence with the SPIRIT guidelines.
2.4 Intervention: In all sub-studies the intervention is inoculation of tumor cells in zebrafish embryos followed by observation of tumor behavior and testing of treatments.
The group in the trial
- Colon cancerTreatment being tested
Tumour tissue from each patients tumour will be implanted in zebrafish embryos and evaluated regarding growth and response to chemotherapy
Treatment: Chemotherapy drug
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer
- Plain-language title
- Tests colon cancer tumor tissue grown in zebrafish embryosGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 21 February 2024