Checks a CT-based method for predicting femur fracture risk in osteoporosis
Tests whether a CT scan of the femur predicts fracture risk in people with osteoporosis.
Plain-language title generated from the registry record
Registry title: Clinical Validation of BBCT-hip
Key facts
- Where
- Bologna, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 65 and 85 years old?
Source: NCT06270758, who can take part
Where in Italy
- Rizzoli Orthopaedic InstituteBologna, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituto Ortopedico Rizzoli
- Trial code
- NCT06270758
- Record updated
- 22 May 2026
- Original description
The clinical study is aimed at assessing the accuracy of the in silico methodology BBCT-hip. BBCT-hip takes as inputs the subject-specific height and weight, and the CT scan of his femur to predict the risk of fracture for the femur upon falling. In the study, 150 subjects who suffered from a fracture will be enrolled, in addition to 150 control subjects. CT scans will be carried out for both groups (no later than 3 months for the fracture group) and BBCT-hip run,in order that the risk of fracture will be obtained. First, a transversal study will be performed, where the stratification accuracy of BBCT-hip will be assessed in terms of the ability of the predicted risk of fracture to separate fracture and control subjects. Furthermore, the control subjets will be followed up to assess BBCT-hip predictive accuracy through a longitudinal study.Read full original descriptionShow less
Clinical Validation of BBCT-hip Methodology for Femur Fracture Risk Prediction
The clinical study is aimed at assessing the accuracy of the in silico methodology BBCT-hip. BBCT-hip takes as inputs the subject-specific height and weight, and the CT scan of his femur to predict the risk of fracture for the femur upon falling. In the study, 150 subjects who suffered from a fracture will be enrolled, in addition to 150 control subjects. CT scans will be carried out for both groups (no later than 3 months for the fracture group) and BBCT-hip run,in order that the risk of fracture will be obtained. First, a transversal study will be performed, where the stratification accuracy of BBCT-hip will be assessed in terms of the ability of the predicted risk of fracture to separate fracture and control subjects. Furthermore, the control subjets will be followed up to assess BBCT-hip predictive accuracy through a longitudinal study.
Inclusion: caucasic post-menopausal women resident in Emilia-Romagna; menopause (>= 45 years).
Exclusion: Long-term continuous therapy (>3 months) with corticosteroids and proton pump inhibitors or aromatase inhibitors; Previous femur fractures; Chronic diseases with severe organ failure / endocrine diseases of parathyroid, thyroid, adrenal gland / intestinal malabsorption, osteomalacia / Paget bone / rheumatoid arthritis. Neurodegenerative diseases; tumours; not free living; Presence of hip/knee prosthesis; only for the fracturegroup:; presence of fixation devices after the fracture; femur fracture due to high energy trauma.