Tests brief low-oxygen breathing to study strength in multiple sclerosis
Tests short low-oxygen breathing to see effects on ankle strength in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Intermittent Hypoxia in Persons With Multiple Sclerosis
Key facts
- Where
- Chicago, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06276634, who can take part
Where in United States
- Shirley Ryan AbilityLabChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shirley Ryan AbilityLab
- Trial code
- NCT06276634
- Record updated
- 20 March 2026
- Original description
This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low levels of oxygen is called Acute Intermittent Hypoxia (AIH), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. Previous studies have shown that AIH is a safe and effective way to increase strength in persons with MS. Here the investigators aim to look at brain activation and ankle strength before and after AIH to gain a better understanding of how the AIH may improve strength in those persons with MS.Read full original descriptionShow less
Intermittent Hypoxia Initiated Motor Plasticity in Individuals With Multiple Sclerosis
This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low levels of oxygen is called Acute Intermittent Hypoxia (AIH), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. Previous studies have shown that AIH is a safe and effective way to increase strength in persons with MS. Here the investigators aim to look at brain activation and ankle strength before and after AIH to gain a better understanding of how the AIH may improve strength in those persons with MS.
Inclusion: Diagnoses of relapsing form of MS (including relapsing-remitting MS and secondary-progressive MS); Expanded Disability Status Scale (EDSS) score of at least 3 and no more than 6.5; Motor Functional System Scale (FSS) between 2-4; Relapse free for at least 1 year; Age ≥ 18 years and ≤ 75 years; Safe to be scanned based on MRI questionnaire; Participants using dalfampridine will be eligible if taking the same daily dose for at least 2 months prior to screening.
Exclusion: Active contrast-enhancing MS lesions, or diffusion positive lesions suggestive of acute cerebrovascular disease on baseline MRI scan; Uncontrolled hypertension (Systolic between 85 and 140, diastolic between 90 and 55); History of epilepsy; Chronic obstructive pulmonary disease; Uncontrolled Sleep apnea; Pregnancy.