Studying how genetic changes affect diabetes risk genes in type 2 diabetes
Examines gene changes linked to type 2 diabetes in patients and healthy people.
Plain-language title generated from the registry record
Registry title: Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls
Key facts
- Where
- Xuzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 70 years old?
Source: NCT06277466, who can take part
Where in China
- China, Jiangsu, Department of EndocrinologyXuzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Affiliated Hospital of Xuzhou Medical University
- Trial code
- NCT06277466
- Record updated
- 28 February 2024
- Original description
In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression.Read full original descriptionShow less
Department of Pharmacy, the Affiliated Hospital of Xuzhou Medical University
In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression.
Participants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM susceptibility genes expression in the fresh peripheral plasma. The normal pancreatic tissues or adjacent tissues of pancreatic cancer were also collected to identify the expression differences of T2DM susceptibility genes under different genotypes.
Inclusion: no drug therapy; 25 to 70 years old; Hemoglobin A1c (HbA1c) 7%-12%; BMI 20-35 kg/m2; Stable body weight (≤10% change within 3 months)（For newly diagnosed patients with T2DM）; 25 to 60 years old; BMI 19-26 kg/m2; in good health, with no abnormalities of motor system, digestive system, respiratory system, urogenital system, blood system, circulatory system, nervous/mental system, endocrine system, etc（For healthy subjects）; 20-80 years old; surgical resection of part or all of the pancreas; pancreatic lesions confirmed by enhanced CT or magnetic resonance (MR) examination or confirmed by intraoperative and postoperative pathology（For the patients in general surgical）.
Exclusion: had taken antidiabetic drugs; Long-term use of drugs that affect pancreatic function; had a history of pancreatic surgery; Complicated with severe organ lesions.