Tests GLP-1 drugs' effect on body fat in people with obesity
Studies how GLP-1 drugs affect fat tissue in adults with obesity having bariatric surgery.
Plain-language title generated from the registry record
Registry title: Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
Key facts
- Where
- Nice, FranceSee the site
Where in France
- Chu de Nice Hopital de L'ArchetNice, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Universitaire de Nice
- Trial code
- NCT06278285
- Record updated
- 27 March 2026
- Original description
Normalizing weight gain and preventing the redistribution of body fat is a major health issue, and could help prevent the onset of various symptoms of metabolic syndrome. Above all, it is important to understand the mechanisms by which these different treatments affect adipose tissue. To this end, the investigators will first study the impact of GLP-1 analogues on adipose tissue. The main objective is to show that subjects treated with a GLP-1 agonist have a significant change in their oxytocin levels compared with subjects not treated with a GLP-1 agonist.Read full original descriptionShow less
Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
Normalizing weight gain and preventing the redistribution of body fat is a major health issue, and could help prevent the onset of various symptoms of metabolic syndrome. Above all, it is important to understand the mechanisms by which these different treatments affect adipose tissue. To this end, the investigators will first study the impact of GLP-1 analogues on adipose tissue. The main objective is to show that subjects treated with a GLP-1 agonist have a significant change in their oxytocin levels compared with subjects not treated with a GLP-1 agonist.
Inclusion: Patient over 18 years of age; Patient able to read and understand the information/consent leaflet; Patient with BMI > 35 with at least one comorbidity. Or BMI > 40; Indication for digestive surgery validated in a multidisciplinary consultation meeting and prior agreement accepted by the CPAM; Membership of a social security scheme; Patient's signed informed consent; For subjects in the GLP-1 analogue group: GLP-1 analogue taken for at least 3 months; For non-GLP-1 analogue group: never taken GLP-1 analogues.
Exclusion: Pregnant or breast-feeding women; Vulnerable patients (under guardianship); Patients deprived of liberty.