Collects blood and other samples from people with heart failure to study
Collects blood and other samples from adults with heart failure to study how it develops.
Key facts
- Who runs it
- National Heart, Lung, and Blood Institute (NHLBI)
- Where
- Baltimore and Falls Church, United StatesSee the 2 sites
- Trial code
- Registry title
- Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)
- Status
- Enrolling by invitation
- People taking part
- 2,000 people, planned
- Starts
- 18 Nov 2026
- Expected to end
- 30 Apr 2034
- Type of study
- Observational
- Record updated
- 13 November 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with active heart failure. They give a blood sample at one visit so researchers can study proteins and other factors linked to heart function.
- Age
- 18 to 100 years
- Sex
- All sexes can join.
- Disease stage
- Active heart failure, with signs or symptoms linked to heart failure, noted by a heart doctor in the medical record.
- Earlier treatment
- People who have had a ventricular assist device or a heart transplant cannot join.
Main reasons for not taking part
- Has had a ventricular assist device
- Has had a heart transplant
- Lives outside the area chosen for the study when joining
- Cannot or does not want to give consent or follow the study activities
The registry criteria, word for word
Show all 9 criteriaShow less
Who cannot take part
- History of ventricular assist device
- History of cardiac transplant
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Living or residing outside of the geographic location designated for the study at the time of enrollment
Other criteria
- INCLUSION CRITERIA:; In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Clinical diagnosis of "active" HF documented by a cardiology provider's note in the medical record. Active HF is the presence of signs or symptoms that are deemed to be related to heart failure, as documented in the participants' medical records
- Able and willing to undergo the consent process and provide consent
- Willing to comply with required study activities
- 18 years of age or older
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Where in United States
- University of Maryland School of MedicineBaltimore, United StatesEnrolling by invitation
- Inova Fairfax HospitalFalls Church, United StatesEnrolling by invitation
About the trial
What the trial wants to find out
Background:
Read full original descriptionShow less
More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year. Treatments have improved in recent years, but researchers want to understand more about how HF develops. To do this, they need to compare blood and other samples from many people with HF.
Objective:
To collect blood and other samples from people with HF. These samples will be used to identify and study proteins and other factors that may lead to decreased heart function over time.
Eligibility:
People aged 18 years and older with heart failure.
Design:
Participants will be asked to join the study based on a review of their medical records.
They will have 1 study visit. They will provide a blood sample: About 3 tablespoons will be collected from a needle inserted into a vein.
Other tests are optional: Participants may provide urine and stool samples. They may have a cotton swab rubbed on the inside of the mouth to collect DNA.
Participants may also take 3 questionnaires. They will answer questions about dietary, social, and other factors that affect their health. Participants will receive compensation.
Researchers will follow the participants health by monitoring their medical records for up to 5 years.
The group in the trial
- Participants with heart condition
Heart Failure
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Multi-scale Phenotyping of Heart Failure: From Precision Phenotyping to Population Inference (PHENO-HEART)
- Plain-language title
- Collects blood and other samples from people with heart failure to studyGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Fit questions
- Built from NCT06280820, who can take part
- Record updated
- 13 November 2026