Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations
Key facts
- Who runs it
- NYU Langone Health
- Where
- Brooklyn, New York, and Tallahassee, United StatesSee the 3 sites
- Trial code
- Status
- Completed
- People taking part
- 76 people enrolled
- Started
- 14 Oct 2024
- Ended
- 16 Sept 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Skills Training in Affective and Interpersonal Regulation with Narrative Therapy (STAIR-NT)
- Treatment as Usual
- Record updated
- 10 November 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- must be 18 years or older,
- be a patient at the START clinic receiving methadone for treatment of opioid use disorder,
- self-report 10+ days of co-use of cocaine and illicit opioids in the past 30-days,
- meet the criteria for stimulant use disorder (cocaine type; mild, moderate or severe) and a score of 3≥ on the PC-PTSD-5
Who cannot take part
- having received clinical care from the interventionist(s) in the past 30 days
- cognitive impairment that would interfere with their ability to understand study participation as assessed by the researcher,
- does not speak/understand English at a conversational level,
- plans to leave the START clinic in the next 60 days,
- patients who missed methadone doses (inactive) for 30 days or more, or
Where in United States
- START Treatment and Recovery CentersBrooklyn, United States
- NYU Langone HealthNew York, United States
- Florida State UniversityTallahassee, United States
About the trial
What the trial wants to find out
During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulant-opioid polysubstance use. The study aims to adapt STAIR-NT to a massed treatment schedule. Once an adapted protocol is complete, it will be tested for feasibility, acceptability, and short-term polysubstance and PTSD symptomology outcomes in a pilot randomized control trial (RCT) of 80 participants. Participants who screen eligible and consent will be randomized 1:1 to the adapted STAIR-NT intervention or treatment as usual (TAU) using randomization blocks of two and two and four via a computer-generated randomization sequence. Participants assigned to the intervention will receive the adapted massed delivery of STAIR-NT by trained counselors.
The 2 groups in the trial
- Adapted STAIR-NT InterventionTreatment being tested
Treatment: Skills Training in Affective and Interpersonal Regulation with Narrative Therapy (STAIR-NT)
- Treatment as Usual (TAU)Existing treatment, for comparison
Treatment: Treatment as Usual
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 10 November 2026