Tests CPAP breathing device in adults with severe asthma and sleep apnea
Tests whether a nighttime breathing machine helps asthma control in adults with sleep apnea.
Key facts
- Who runs it
- Hospital Clinic of Barcelona
- Where
- Barcelona, SpainSee the site
- Trial code
- Registry title
- Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial
- Status
- Recruiting
- People taking part
- 138 people, planned
- Started
- 29 Feb 2024
- Expected to end
- Dec 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- CPAP treatment
- Hygienic and dietary advice
- Record updated
- 21 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with severe asthma that is not under control and obstructive sleep apnea, to see how CPAP treatment affects their asthma control.
- Age
- Over 18 years.
- Sex
- All sexes can join.
- Disease stage
- Severe uncontrolled asthma (by the GEMA or GINA criteria), no hospital stay in the month before joining, and sleep apnea with an apnea hypopnea rate of 15/hour or more.
- Earlier treatment
- People who have had CPAP treatment before cannot join.
- Biomarker or test result
- Epworth Sleepiness Scale score of 10 or less.
Main reasons for not taking part
- Previous CPAP treatment
- Central sleep apnea or Cheyne-Stokes breathing
- Other sleep disorders such as narcolepsy, restless leg syndrome or chronic insomnia
- Resistant hypertension
- Active smoking
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Age >18 years
- Diagnosis of severe uncontrolled asthma according to the criteria of the Spanish Asthma Management Guide (GEMA) or the Global Initiative for Asthma (GINA) and no hospitalizations the month prior to inclusion in the study
- Apnea hypopnea rate greater than or equal to 15/hour
- Punctuation in the Epworth Sleepiness Scale ≤10
- Obtaining informed consent
Who cannot take part
- Previous treatment with CPAP
- Unstable comorbidities or medications may interfere with asthma control
- Other sleep disorders: narcolepsy, restless leg syndrome, chronic insomnia,
- Resistant hypertension
- Patient with central sleep apnea or Cheyne-Stokes respiration
- Active Smoking
- Pregnancy
- Any process that reduces life expectancy to <1 year,
- Any medical or social factor that may limit CPAP compliance
Where in Spain
- Hospital Clinic BarcelonaBarcelona, SpainContact: Mireia Dalmases, MDTaking people
About the trial
What the trial wants to find out
The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA)
The 2 groups in the trial
- Conservative treatmentExisting treatment, for comparison
Subjects allocated to this arm will receive hygienic and dietary measures counselling
Treatment: Hygienic and dietary advice
- CPAP treatmentTreatment being tested
Subjects allocated to this arm will receive treatment with continuous positive airway pressure (CPAP)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effect of CPAP Treatment on Asthma Control in Patients With Severe Uncontrolled Asthma and Obstructive Sleep Apnea: The ASTHMA-SLEEP Study
- Plain-language title
- Tests CPAP breathing device in adults with severe asthma and sleep apneaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 21 September 2026