Studies Blood Vessel Function in People with High-Normal Blood Pressure
Observes blood vessel lining function in adults with prehypertension, hypertension, and healthy controls.
Plain-language title generated from the registry record
Registry title: Endothelial Function in Prehypertension
Key facts
- Where
- Osijek, CroatiaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with normal blood pressure, high-normal blood pressure (prehypertension) or grade I hypertension. It studies how blood vessel function changes at these blood pressure levels.
- Age
- 18 Years to 69 Years
- Sex
- Women and men can join.
- Disease stage
- Normal blood pressure (129/85 mmHg or less), prehypertension (130-139/85-89 mmHg), or grade I hypertension (140-150/90-100 mmHg).
- Earlier treatment
- People taking oral contraceptives or any drugs that could affect the blood vessel lining (endothelium) cannot join.
Main reasons for not taking part
- Cardiovascular diseases, except grade I hypertension (BP 140-150/90-100 mmHg)
- Diabetes
- Kidney disease
- Cerebrovascular diseases
- Peripheral artery disease
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 69 years old?
Source: NCT06316271, who can take part
Where in Croatia
- Faculty of Medicine OsijekOsijek, CroatiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Josip Juraj Strossmayer University of Osijek
- Trial code
- NCT06316271
- Record updated
- 18 March 2024
- Original description
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and macrocirculation, reduces re-endothelialization potential of human endothelial progenitor cells (EPCs) and increases the level of endothelial extracellular vesicles (EVs), which are accompanied by increased oxidative stress level. Furthermore, initial vascular and left ventricle (LV) remodeling contributes to changes in systemic hemodynamics and may be influenced by altered regulatory role of renin-angiotensin system (RAS) and autonomic nervous system (ANS) in PreHT but otherwise healthy individuals. To distinguish high normal blood pressure effect from those considered normal or high, study will be performed in three groups of individuals: prehypertensive (BP 130-139/85-89 mmHg), hypertensive (stage I, BP 140-150/90-100 mmHg), and controls (BP less than or equal to 129/85 mmHg). Altogether, the impairment of normal vascular relaxation mechanisms, endothelial activation as well as vascular and LV remodeling could play crucial role in increased cardiovascular risk and CVDs incidence in PreHT individuals. Moreover, the prognostic significance of assessing endotehlial dysfunction in hypertension (as well as in PreHT) is yet to be established.Read full original descriptionShow less
Endothelial Dysfunction and Cardiovascular Remodeling in Pathophyisiology of Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and macrocirculation, reduces re-endothelialization potential of human endothelial progenitor cells (EPCs) and increases the level of endothelial extracellular vesicles (EVs), which are accompanied by increased oxidative stress level. Furthermore, initial vascular and left ventricle (LV) remodeling contributes to changes in systemic hemodynamics and may be influenced by altered regulatory role of renin-angiotensin system (RAS) and autonomic nervous system (ANS) in PreHT but otherwise healthy individuals. To distinguish high normal blood pressure effect from those considered normal or high, study will be performed in three groups of individuals: prehypertensive (BP 130-139/85-89 mmHg), hypertensive (stage I, BP 140-150/90-100 mmHg), and controls (BP less than or equal to 129/85 mmHg). Altogether, the impairment of normal vascular relaxation mechanisms, endothelial activation as well as vascular and LV remodeling could play crucial role in increased cardiovascular risk and CVDs incidence in PreHT individuals. Moreover, the prognostic significance of assessing endotehlial dysfunction in hypertension (as well as in PreHT) is yet to be established.
Inclusion: adults of both sexes with normotensive, prehypertensive and grade I hypertension blood pressure values.
Exclusion: taking oral contraceptives or any drugs that could affect the endothelium; cardiovascular diseases, but grade I hypertension (BP 140-150/90-100 mmHg); diabetes; kidney disease; cerebrovascular diseases; peripheral artery disease.