Measuring Lung Tumour Movement During Breathing With Dynamic MRI
Tests dynamic MRI to measure breathing-related movement of lung tumours before radiotherapy in adults.
Plain-language title generated from the registry record
Registry title: RealMove (Lung): Assessing Tumour Motion With Dynamic MRI
Key facts
- Where
- Stockholm, SwedenSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who will have stereotactic body radiotherapy (SBRT) for one or more lung targets below the carina. It compares how a tumour moves on dynamic MRI and on 4D CT.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- One or more lung targets (non-small cell lung cancer or metastases) below the carina, accepted for SBRT
Main reasons for not taking part
- Pregnancy or breastfeeding, or planned pregnancy or breastfeeding, during treatment
- A medical reason why an MRI scan cannot be done
- Cannot lie still for at least 30 minutes
- Not enough Swedish skills or understanding to follow the study information and fill in the questionnaire
- Otherwise unable to take part in the study
Read by machine on 12 November 2026.
Where in Sweden
- Karolinska University HospitalStockholm, SwedenContact: Eva Onjukka, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Region Stockholm
- Trial code
- NCT06322329
- Record updated
- 2 September 2025
- Original description
The study aims to develop an improved method to tailor the geometric safety margin when treating with stereotactic body radiotherapy (SBRT), to avoid tumour cells being missed during irradiation and to limit the exposure of normal tissues as much as possible. Dynamic magnetic resonance imaging (MRI) is assumed to represent the tumour motion during the respiratory cycle more realistically, compared to 4-dimensional computed tomography (4D CT), thanks to its high temporal resolution and the possibility to image the motion over a longer period of time. Patients receiving SBRT for a pulmonary target located below the level of the carina are included in the study, and the hypothesis will be tested through a comparison of the tumour amplitude measured with each modality. Furthermore, the predictive value of the image series acquired at treatment planning, for the motion patterns observed at each treatment fraction, will be evaluated through repeated 4D CBCT acquisitions.Read full original descriptionShow less
RealMove (Lung): Assessing Tumour Motion With Dynamic MRI
The study aims to develop an improved method to tailor the geometric safety margin when treating with stereotactic body radiotherapy (SBRT), to avoid tumour cells being missed during irradiation and to limit the exposure of normal tissues as much as possible. Dynamic magnetic resonance imaging (MRI) is assumed to represent the tumour motion during the respiratory cycle more realistically, compared to 4-dimensional computed tomography (4D CT), thanks to its high temporal resolution and the possibility to image the motion over a longer period of time. Patients receiving SBRT for a pulmonary target located below the level of the carina are included in the study, and the hypothesis will be tested through a comparison of the tumour amplitude measured with each modality. Furthermore, the predictive value of the image series acquired at treatment planning, for the motion patterns observed at each treatment fraction, will be evaluated through repeated 4D CBCT acquisitions.
Inclusion: Accepted for SBRT treatment of one or more caudally situated lung targets (NSCLC or metastases), i.e. below the carina; Age ≥ 18 years; Adequate clinical condition to maintain immobilised position for at least 30 minutes; Adequate Swedish skills and cognitive function to understand study information and to fill in the questionnaire.
Exclusion: Pregnancy or breastfeeding, or planned pregnancy or breastfeeding, during treatment; Contraindication for MRI examination; Otherwise incapable of participating in study.