Testing high-intensity aerobic exercise for fatigue in Parkinson's disease
Tests whether 12 weeks of hard aerobic exercise eases fatigue in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Exercise as Treatment of Fatigue in Parkinson´s Disease
Key facts
- Where
- Aarhus, DenmarkSee the site
Where in Denmark
- Exercise Biology, Dep. of Public Health, Aarhus UniversityAarhus, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Aarhus
- Trial code
- NCT06324422
- Record updated
- 10 May 2024
- Original description
The primary goal of this study is to test whether 12 weeks of high-intensity aerobic exercise can treat fatigue in Parkinsons disease (PD).Read full original descriptionShow less
Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?
The primary goal of this study is to test whether 12 weeks of high-intensity aerobic exercise can treat fatigue in Parkinsons disease (PD).
The study will be a randomized multi-site controlled trial with follow up. Clinically fatigued persons with PD will be allocated to either 12 weeks of high-intensity aerobic exercise or to a waitlist control group receiving high-intensity resistance exercise after 24 weeks of habitual lifestyle (control period).
It is hypothesized that persons with PD receiving 12 weeks of high-intensity aerobic exercise will show superior effects on perceived fatigue (i.e., clinical relevant reductions) when compared to the PD control group (primary hypothesis), and that these effects are sustained after 12-weeks of follow up (secondary hypothesis).
Inclusion: Minimum 40 years; Diagnosed with Idiopathic Parkinsons disease; Stable in medical treatment for six month; Able to transport themselves to and from exercise and testing sessions (with or without assistance); H\&Y score of three or lower.
Exclusion: Significant medical comorbidities such as cardiovascular, respiratory, orthopedic, metabolic, or other neurological disorders; Performing high-intensity exercise more than two times per week; Cognitive dysfunction that prevents following or understanding instructions related to training and testing (answering questionnaires); Known depression or alcohol abuse.