Tests thiamine, a vitamin, in older adults having heart bypass surgery
Compares thiamine with placebo in older adults with heart disease having bypass surgery.
Plain-language title generated from the registry record
Registry title: Thiamine Intervention and Coronary Artery Bypass Grafting
Key facts
- Where
- Los Angeles, United StatesSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 80 years old?
Source: NCT06326996, who can take part
Where in United States
- UCLALos Angeles, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Los Angeles
- Trial code
- NCT06326996
- Record updated
- 6 November 2026
- Original description
The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.Read full original descriptionShow less
Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.
The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.
Inclusion: Patients with Coronary Heart Disease (CHD) scheduled for Bypass Grafting (CABG); Thiamine deficiency before CABG; European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) >1.5%; Off-pump surgery.
Exclusion: Dementia at baseline [Montreal Cognitive Assessment (MoCA) <21 within 5 days before CABG]; Known thiamine allergy; Unable to give consent due to illness; History of hyperlactatemia; Recent (within several years and/or up to the judgment of the PI/co-PIs) cerebral incidents (seizure or head trauma resulting in loss of consciousness and/or concussion); Stroke; Diagnosed psychiatric diseases (clinical depression, schizophrenia, manic-depression); Patients with history of alcohol or substance abuse; Acute or chronic infections (tuberculosis, hepatitis, or encephalopathy); Diagnosed neuro-degenerative diseases (Alzheimer's or Parkinson's disease); Chronic immunodeficiency (including HIV); Uncontrolled blood glucose levels; Current in-take of thiamine; Congenital brain deficits will also be excluded.