Tests dialysis methods and salt levels in adults with kidney failure
Compares dialysis treatments and dialysate sodium levels on microcirculation and stored salt in kidney failure.
Plain-language title generated from the registry record
Registry title: The Microcirculation, Dialysis Modality and Sequestered Salt
Key facts
- Where
- Amstelveen and Amsterdam, NetherlandsSee the 2 sites
Where in Netherlands
- Niercentrum aan de Amstel (Elyseklinieken)Amstelveen, NetherlandsTaking people
- Dianet AmsterdamAmsterdam, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Amsterdam UMC, location VUmc
- Trial code
- NCT06327750
- Record updated
- 11 September 2026
- Original description
The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in adult prevalent end-stage kidney disease (ESKD) patients treated with hemodialysis (HD) or hemodiafiltration (HDF). The main questions it aims to answer are:Read full original descriptionShow less
The Microcirculation, Dialysis Modality and Sequestered Salt
The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in adult prevalent end-stage kidney disease (ESKD) patients treated with hemodialysis (HD) or hemodiafiltration (HDF). The main questions it aims to answer are:
1. What are the effects on the sequestered sodium content and microcirculation after 4 weeks of treatment with the following dialysis modes?
* HDF with an expected zero diffusive sodium balance (Dialysate sodium concentration (DNa)= Plasma sodium concentration (PNa)) compared to * HDF with an expected diffusive sodium efflux (DNa < PNa, difference 3 mmol/L) compared to * HD with an expected zero diffusive sodium balance (DNa = PNa) compared to * HD with an expected diffusive sodium efflux (DNa < PNa, difference 3 mmol/L) compared to * Isolated ultrafiltration for 30 minutes followed by HD with an expected zero diffusive sodium balance (DNa = PNa) 2. Are the SSC and MC interrelated in this patient group?
This study is a randomized cross-over trial. Participants will be subjected to the abovementioned dialysis treatment modes in random order.
Inclusion: Age ≥18 years; Treatment with HD or HDF 3 x per week during at least 4 hours for at least 3 months; Blood flow rate feasiblity of ≥350 ml/min; Residual diuresis <200 ml/day; Plasma Na before dialysis 137-145 mmol/L at baseline; spKt/Vurea ≥ 1.2; Ability to understand study procedures and willingness to provide informed consent.
Exclusion: Expected transplantation within 6 months; Metal implants (e.g. implantable cardioverter defibrillators); Life expectancy < 3 months due to non-renal disease; Severe incompliance to dialysis procedure and accompanying prescriptions, especially frequency and duration of dialysis treatment; Access recirculation > 10%; Participation in another clinical intervention trial; Severe obesity (MRI Ø 60 cm ≈ abdominal circumference ≤ 188 cm); Claustrophobia.