Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA
Key facts
- Who runs it
- Thammasat University Hospital
- Where
- Thailand1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 80 people, planned
- Started
- 1 Apr 2024
- Planned end
- 31 Aug 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Mirogabalin
- Pregabalin
- Record updated
- 7 August 2026
Who can take part
- Age
- 50 years to 85 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Age 50-85 years old
- Unilateral primary osteoarthritis undergoing primary TKA
- ASA I-III
Who cannot take part
- Taking gabapentinoid within 3 months before surgery
- History of previous knee surgery
- Allergy to drug in this study
- Severe liver disease
- GFR \<60
- Cannot underwent spinal anesthesia and adductor canal block
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 85 years old?
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty.
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The main question[s] it aims to answer are:
• Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty.
Participants will randomized to mirogabalin or pregabalin group and will take the drug for 2 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.
The 2 groups in the trial
- MirogabalinTreatment being tested
Participants will receive 5 mg of mirogabalin, twice a day, after breakfast and dinner, for 2 weeks.
- PregabalinExisting treatment, for comparison
Participants will receive 75 mg of pregabalin, once a day before bedtime, for 2 weeks.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparison Efficacy of Mirogabalin and Pregabalin in Total Knee Arthroplasty. a Randomized Controlled Trial
- Fit questions
- Built from NCT06328062, who can take part
- Record updated
- 7 August 2026