Studying gut immune cells in people with neurologic disease
Studies gut immune cells from colon biopsies in people with multiple sclerosis or Parkinson disease.
Plain-language title generated from the registry record
Registry title: Intestinal Immunity in Neurologic Disease
Key facts
- Where
- North Haven, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT06329453, who can take part
Where in United States
- Yale MS ClinicNorth Haven, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Yale University
- Trial code
- NCT06329453
- Record updated
- 27 May 2026
- Original description
The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.Read full original descriptionShow less
Intestinal Immunity in Neurologic Disease
The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.
Inclusion: Age 18 and up; ONE of the following:; Recommended to under a screening colonoscopy (+/- upper endoscopy) as part of standard of care. This includes healthy individuals as well as those with neurologic and/or autoimmune diseases. OR; Willing to undergo research colonoscopy (+/- upper endoscopy) for research.
Exclusion: Currently pregnant. Women of childbearing potential would perform a point of care urine pregnancy test prior to colonoscopy/endoscopy; Systemic corticosteroid use (equivalent of prednisone 10 mg per day or higher for >5 days) within 2 weeks of colonoscopy; Known or suspected, chronic inflammatory gastrointestinal disease (e.g. inflammatory bowel disease); Known, acute or chronic infections; Malignancy, diagnosed or treated within the last 5 years; History of major GI surgery (e.g. colon resection, gastric bypass); Bleeding disorder, or on anticoagulant medication; Other medical condition that, in the judgement of the investigator, would lead to higher-than-expected risks of biopsy; Allergy to MAC anesthesia or other drugs used pursuant to standard of care for biospecimen collection; Systemic antibiotic (PO or IV) use within 3 months of colonoscopy; Probiotic use within 2 weeks of procedure.