Building a lab model of endometrial tissue to study endometriosis treatments
Tests whether lab-grown endometrial tissue can predict how women with endometriosis respond.
Plain-language title generated from the registry record
Registry title: Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
Key facts
- Where
- Bron and Lyon, FranceSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT06331676, who can take part
Where in France
- Hôpital Femme Mère Enfant / GHEBron, FranceTaking people
- Hôpital de la Croix-Rousse / GHNLyon, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospices Civils de Lyon
- Trial code
- NCT06331676
- Record updated
- 30 January 2026
- Original description
Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women.Read full original descriptionShow less
Developing a Complex ex Vivo Endometrial Tissue Model Based on Patient Biopsies to Assess and Optimise the Response to Current and Potential Treatments for Endometriosis
Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women.
There is no cure for endometriosis. Hormonal treatments should be the first line therapy. The benefit-risk ratio of symptomatic treatment with hormone therapy varies greatly from one woman to another. The pathophysiology of endometriosis and the mechanisms of action of these treatments are still poorly understood. This may be due to the lack of an optimal experimental model for studying the disease.
The aim of this project is to develop a complex ex vivo endometrial model recapitulating the organisation and properties of the human endometrium using innovative tissue bioengineering methods. This model will make it possible to develop a pre-clinical approach that predicts individual response to different types of hormonal treatment in order to optimise therapeutic choices and provide a better understanding of the effects of these treatments.
Inclusion: Female; People aged between 18 and 50; Person who has or has had hormonal contraceptive treatment; A person who has given written consent; Person diagnosed with a benign gynaecological pathology not affecting the endometrium and requiring hysterectomy, hysteroscopy or laparoscopy or with a diagnosis of endometriosis and requiring laparoscopy or hysterectomy; Person affiliated to the french social security.
Exclusion: Pregnant at the time of sampling or within 3 months prior to sampling; Anyone who has received hormonal treatment with hormones other than steroids in the three months prior to sampling; Anyone with a personal history of cancer of the breast, ovary, endometrium or cervix; People with Lynch syndrome; Breast-feeding women; Women undergoing physiological menopause; Anyone with a non-hormonal contraceptive intrauterine device (copper coil); Persons under legal protection (guardianship, curatorship); Persons deprived of their liberty by judicial or administrative decision; Persons with a body mass index (BMI) of less than 18.5 or more than 30.