Tests carrot juice in adults after bowel polyp removal
Compares carrot juice rich in polyacetylenes with placebo juice in adults after polyp removal.
Plain-language title generated from the registry record
Registry title: Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps
Key facts
- Where
- Odense, DenmarkSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who had a large bowel polyp (adenoma) or an early cancer removed, and who will drink carrot juice or placebo juice daily for 1 year.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Any type of resection for adenomas larger than 20 mm (endoscopically evaluated), or endoscopically resected T1 cancers.
- Earlier treatment
- Must have had a polyp or early cancer removed. Chronic use of COX inhibitors or immunosuppressive agents is not allowed. Current cancer treatment is not allowed.
Main reasons for not taking part
- High-risk only because of many small polyps (more than 4)
- Pregnancy
- Known relevant allergies
- Chronic use of COX inhibitors (such as Aspirin or Ibuprofen) or immunosuppressive agents (such as Methotrexate, Azathioprine or glucocorticoids)
- Another cancer under treatment, or severe comorbidity NYHA III-IV, or Lynch syndrome
Read by machine on 9 November 2026.
Where in Denmark
- Department of Surgery, Odense University HospitalOdense, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Odense University Hospital
- Trial code
- NCT06335420
- Record updated
- 20 November 2025
- Original description
The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel.Read full original descriptionShow less
Polyp Prophylactic Properties of Polyacetylenes in Patients With Previous Polypectomy
The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel.
The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans?
Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar.
Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.
Inclusion: Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers; Acceptance of the treatment and follow-up program; Capability to understand and follow the instructions.
Exclusion: Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids); Known relevant allergies; Patients with different neoplastic disease under treatment (Chemo-/Radio-/Imunotherapy); Lynch syndrome; Patients allocated to "high-risk" group because of many small polyps (>4); Pregnancy; Severe comorbidity NYHA III-IV.