Taking people in United StatesPhase 3

Comparing Two Antibody Treatments for Low Tumor Burden Follicular Lymphoma

Compares rituximab and mosunetuzumab in adults with slow-growing follicular lymphoma.

Plain-language title generated from the registry record
Registry title: Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Key facts

Where: Ames, Anaconda, Ankeny, Ann Arbor, Appleton, Ashland, Atlanta, Augusta, Aurora, Aventura, Avon, Baltimore, Baton Rouge, Battle Creek, Beachwood, Bend, Bethesda, Bettendorf, Beverly Hills, Billings, Birmingham, Bloomington, Boise, Boone, Bozeman, Brainerd, Brighton, Brownstown, Burnsville, Caldwell, Canton, Cape Girardeau, Carthage, Cedar Rapids, Chapel Hill, Charleston, Charlotte, Charlottesville, Chelsea, Chesterfield, Chicago, City of Saint Peters, Clemmons, Cleveland, Clinton, Clinton Township, Clive, Coeur d'Alene, Columbus, Concord, Coon Rapids, Coral Gables, Coral Springs, Creve Coeur, Crown Point, Danville, Dearborn, Decatur, Deer River, Deerfield Beach, Des Moines, Detroit, Dixon, Doral, Duarte, Duluth, Durham, Dyer, Eau Claire, Edina, Effingham, Elmhurst, Escanaba, Eureka, Evanston, Fargo, Farmington, Farmington Hills, Fayetteville, Flint, Fort Collins, Fort Dodge, Galesburg, Glenview, Goldsboro, Grand Rapids, Great Falls, Greeley, Green Bay, Hays, Hibbing, Highland Park, Hobart, Hollywood, Houston, Indianapolis, Iowa City, Irvine, Jackson, Jacksonville, Jefferson, Kalamazoo, Kalispell, Kansas City, Kewanee, La Crosse, Lancaster, Lansing, Las Vegas, Lawrence, Leavenworth, Lebanon, Lee's Summit, Little Rock, Livingston, Livonia, Long Beach, Long Branch, Los Angeles, Loveland, Macomb, Manistique, Marshalltown, Marshfield, Mattoon, Memphis, Menomonee Falls, Mentor, Miami, Miami Beach, Milwaukee, Minneapolis, Missoula, Monroe, Mooresville, Mukwonago, Munster, Muskegon, Nampa, Naperville, New Berlin, New Brunswick, New Lenox, Newark, Newberg, Niles, North Miami, Norton Shores, Novi, O'Fallon, Oak Creek, Oconomowoc, Oconto Falls, Oklahoma City, Olathe, Ontario, Orange, Oregon City, Orland Park, Ottawa, Overland Park, Pekin, Pembroke Pines, Peoria, Peru, Philadelphia, Phoenix, Plainfield, Plantation, Pontiac, Portland, Post Falls, Princeton, Providence, Reed City, Reno, Rice Lake, Richmond, Rochester, Rogers, Ruskin, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salina, Salt Lake City, San Antonio, Sandpoint, Sandstone, Shakopee, Sheboygan, Shiloh, South Pasadena, Southfield, Southhaven, Springdale, Springfield, St Louis, Stevens Point, Sturgeon Bay, Sullivan, Tampa, Topeka, Torrance, Traverse City, Tucson, Upland, Urbana, Valparaiso, Virginia, Washington, Washington D.C., Waukee, Waukesha, Webster, Wesley Chapel, West Bend, West Bloomfield, Weston, Westwood, Willow Grove, Winston-Salem, Wyandotte, Wyoming, Yorba Linda, and Ypsilanti, United StatesSee the 288 sites
Phase: Phase 3

Where in United States

Mary Greeley Medical CenterAmes, United StatesTaking people
McFarland Clinic - AmesAmes, United StatesTaking people
Community Hospital of AnacondaAnaconda, United StatesTaking people
UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
ThedaCare Regional Cancer CenterAppleton, United StatesTaking people
ThedaCare Regional Medical Center - AppletonAppleton, United StatesTaking people
Duluth Clinic AshlandAshland, United StatesTaking people
Emory Saint Joseph's HospitalAtlanta, United StatesTaking people
Emory University Hospital MidtownAtlanta, United StatesTaking people
Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
Augusta University Medical CenterAugusta, United StatesTaking people
UCHealth University of Colorado HospitalAurora, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at AventuraAventura, United StatesTaking people
UH Seidman Cancer Center at UH Avon Health CenterAvon, United StatesTaking people
Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesTaking people
LSU Health Baton Rouge-North ClinicBaton Rouge, United StatesTaking people
Our Lady of the Lake Physician GroupBaton Rouge, United StatesTaking people
Bronson Battle CreekBattle Creek, United StatesTaking people
UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
Saint Charles Health SystemBend, United StatesTaking people
Walter Reed National Military Medical CenterBethesda, United StatesTaking people
University of Iowa Healthcare Cancer Services Quad CitiesBettendorf, United StatesTaking people
Tower Cancer Research FoundationBeverly Hills, United StatesTaking people
Billings Clinic Cancer CenterBillings, United StatesTaking people
University of Alabama at Birmingham Cancer CenterBirmingham, United StatesTaking people
Illinois CancerCare-BloomingtonBloomington, United StatesNo longer taking part
Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesTaking people
McFarland Clinic - BooneBoone, United StatesNo longer taking part
Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
Henry Ford Cancer Institute-DownriverBrownstown, United StatesTaking people
Minnesota Oncology - BurnsvilleBurnsville, United StatesTaking people
Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
Illinois CancerCare-CantonCanton, United StatesNo longer taking part
Saint Francis Medical CenterCape Girardeau, United StatesTaking people
Illinois CancerCare-CarthageCarthage, United StatesNo longer taking part
Mercy HospitalCedar Rapids, United StatesTaking people
Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
Medical University of South CarolinaCharleston, United StatesTaking people
Vandalia Health/CAMC Institute for Academic MedicineCharleston, United StatesTaking people
Atrium Health Pineville/LCI-PinevilleCharlotte, United StatesTaking people
Atrium Health University City/LCI-UniversityCharlotte, United StatesTaking people
Carolinas Medical Center/Levine Cancer InstituteCharlotte, United StatesTaking people
Levine Cancer Institute-SouthParkCharlotte, United StatesTaking people
Novant Health Presbyterian Medical CenterCharlotte, United StatesTaking people
University of Virginia Cancer CenterCharlottesville, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
Saint Luke's HospitalChesterfield, United StatesTaking people
Swedish Covenant HospitalChicago, United StatesTaking people
University of Chicago Comprehensive Cancer CenterChicago, United StatesTaking people
Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesTaking people
Wake Forest University at ClemmonsClemmons, United StatesTaking people
Case Western Reserve UniversityCleveland, United StatesTaking people
Southeastern Medical Oncology Center-ClintonClinton, United StatesTaking people
Henry Ford Macomb Hospital-Clinton TownshipClinton Township, United StatesTaking people
UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
Atrium Health Cabarrus/LCI-ConcordConcord, United StatesTaking people
Mercy HospitalCoon Rapids, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at Coral SpringsCoral Springs, United StatesTaking people
Siteman Cancer Center at West County HospitalCreve Coeur, United StatesTaking people
Northwest Cancer Center - Crown PointCrown Point, United StatesTaking people
UChicago Medicine Northwest IndianaCrown Point, United StatesTaking people
Carle at The RiverfrontDanville, United StatesTaking people
Henry Ford Medical Center-FairlaneDearborn, United StatesTaking people
Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
Decatur Memorial HospitalDecatur, United StatesTaking people
Essentia Health - Deer River ClinicDeer River, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, United StatesTaking people
Iowa Methodist Medical CenterDes Moines, United StatesTaking people
UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
Henry Ford HospitalDetroit, United StatesTaking people
Wayne State University/Karmanos Cancer InstituteDetroit, United StatesTaking people
Illinois CancerCare-DixonDixon, United StatesNo longer taking part
UM Sylvester Comprehensive Cancer Center at DoralDoral, United StatesTaking people
City of Hope Comprehensive Cancer CenterDuarte, United StatesTaking people
Essentia Health Cancer CenterDuluth, United StatesTaking people
Duke University Medical CenterDurham, United StatesTaking people
Northwest Oncology LLCDyer, United StatesTaking people
Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
Fairview Southdale HospitalEdina, United StatesTaking people
Minnesota Oncology - EdinaEdina, United StatesTaking people
Carle Physician Group-EffinghamEffingham, United StatesTaking people
Crossroads Cancer CenterEffingham, United StatesTaking people
Elmhurst Memorial HospitalElmhurst, United StatesTaking people
OSF Saint Francis Hospital and Medical GroupEscanaba, United StatesTaking people
Illinois CancerCare-EurekaEureka, United StatesNo longer taking part
NorthShore University HealthSystem-Evanston HospitalEvanston, United StatesTaking people
Essentia Health Cancer Center-South University ClinicFargo, United StatesTaking people
Parkland Health Center - FarmingtonFarmington, United StatesTaking people
Weisberg Cancer Treatment CenterFarmington Hills, United StatesTaking people
Highlands Oncology Group - FayettevilleFayetteville, United StatesTaking people
Cancer Hematology Centers - FlintFlint, United StatesTaking people
Genesys Hurley Cancer InstituteFlint, United StatesTaking people
Genesee Hematology Oncology PCFlint, United StatesNo longer taking part
Cancer Care and Hematology-Fort CollinsFort Collins, United StatesTaking people
Poudre Valley HospitalFort Collins, United StatesTaking people
McFarland Clinic - Trinity Cancer CenterFort Dodge, United StatesTaking people
Illinois CancerCare-GalesburgGalesburg, United StatesNo longer taking part
NorthShore University HealthSystem-Glenbrook HospitalGlenview, United StatesTaking people
Southeastern Medical Oncology Center-GoldsboroGoldsboro, United StatesTaking people
Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
UCHealth Greeley HospitalGreeley, United StatesTaking people
Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesTaking people
Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesTaking people
HaysMedHays, United StatesTaking people
Essentia Health Hibbing ClinicHibbing, United StatesTaking people
NorthShore University HealthSystem-Highland Park HospitalHighland Park, United StatesTaking people
Northwest Cancer Center - HobartHobart, United StatesTaking people
Saint Mary Medical CenterHobart, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at HollywoodHollywood, United StatesTaking people
UT MD Anderson Cancer CenterHouston, United StatesTaking people
Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesTaking people
Saint Catherine HospitalIndianapolis, United StatesTaking people
University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
City of Hope at Irvine LennarIrvine, United StatesTaking people
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
Allegiance HealthJackson, United StatesTaking people
Mayo Clinic in FloridaJacksonville, United StatesTaking people
Southeastern Medical Oncology Center-JacksonvilleJacksonville, United StatesTaking people
McFarland Clinic - JeffersonJefferson, United StatesNo longer taking part
Bronson Methodist HospitalKalamazoo, United StatesTaking people
West Michigan Cancer CenterKalamazoo, United StatesTaking people
Logan Health Medical CenterKalispell, United StatesTaking people
Kansas City Veterans Affairs Medical CenterKansas City, United StatesTaking people
University Health Truman Medical CenterKansas City, United StatesTaking people
University of Kansas Cancer CenterKansas City, United StatesTaking people
University of Kansas Cancer Center - BriarcliffKansas City, United StatesTaking people
University of Kansas Cancer Center - NorthKansas City, United StatesTaking people
Illinois CancerCare-Kewanee ClinicKewanee, United StatesNo longer taking part
Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
City of Hope Antelope ValleyLancaster, United StatesTaking people
University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
OptumCare Cancer Care at CharlestonLas Vegas, United StatesNo longer taking part
OptumCare Cancer Care at Fort ApacheLas Vegas, United StatesNo longer taking part
Lawrence Memorial HospitalLawrence, United StatesTaking people
Veteran Administration Eastern Kansas HealthcareLeavenworth, United StatesNo longer taking part
Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesTaking people
University of Kansas Cancer Center - Lee's SummitLee's Summit, United StatesTaking people
University of Arkansas for Medical SciencesLittle Rock, United StatesTaking people
Cooperman Barnabas Medical CenterLivingston, United StatesTaking people
Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
City of Hope at Long Beach ElmLong Beach, United StatesTaking people
Tibor Rubin VA Medical CenterLong Beach, United StatesTaking people
Monmouth Medical CenterLong Branch, United StatesTaking people
Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
Medical Center of the RockiesLoveland, United StatesTaking people
Illinois CancerCare-MacombMacomb, United StatesNo longer taking part
Schoolcraft Memorial HospitalManistique, United StatesTaking people
McFarland Clinic - MarshalltownMarshalltown, United StatesTaking people
Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesTaking people
Froedtert Menomonee Falls HospitalMenomonee Falls, United StatesTaking people
UH Seidman Cancer Center at Lake Health Mentor CampusMentor, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at KendallMiami, United StatesTaking people
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, United StatesTaking people
Mount Sinai Medical CenterMiami Beach, United StatesTaking people
Medical College of WisconsinMilwaukee, United StatesTaking people
Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
Community Medical CenterMissoula, United StatesTaking people
Atrium Health Union/LCI-UnionMonroe, United StatesTaking people
Novant Health Cancer Institute - MooresvilleMooresville, United StatesTaking people
ProHealth D N Greenwald CenterMukwonago, United StatesTaking people
The Community HospitalMunster, United StatesTaking people
Women's Diagnostic Center - MunsterMunster, United StatesTaking people
Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
Edward Hospital/Cancer CenterNaperville, United StatesTaking people
Froedtert and MCW Moorland Reserve Health CenterNew Berlin, United StatesTaking people
Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesTaking people
UC Comprehensive Cancer Center at Silver CrossNew Lenox, United StatesTaking people
Helen F Graham Cancer CenterNewark, United StatesTaking people
Medical Oncology Hematology Consultants PANewark, United StatesTaking people
Providence Newberg Medical CenterNewberg, United StatesTaking people
Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
University of Miami Sylvester Comprehensive Cancer Center at Sole MiaNorth Miami, United StatesTaking people
Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesTaking people
Henry Ford Medical Center-ColumbusNovi, United StatesTaking people
Henry Ford Health Providence Novi HospitalNovi, United StatesNo longer taking part
Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
Drexel Town Square Health CenterOak Creek, United StatesTaking people
ProHealth Oconomowoc Memorial HospitalOconomowoc, United StatesTaking people
Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, United StatesTaking people
University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
The University of Kansas Cancer Center - OlatheOlathe, United StatesTaking people
Saint Alphonsus Cancer Care Center-OntarioOntario, United StatesTaking people
UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
University of Chicago Medicine-Orland ParkOrland Park, United StatesTaking people
Illinois CancerCare-Ottawa ClinicOttawa, United StatesNo longer taking part
University of Kansas Cancer Center-Overland ParkOverland Park, United StatesTaking people
Illinois CancerCare-PekinPekin, United StatesNo longer taking part
Memorial Hospital WestPembroke Pines, United StatesTaking people
Illinois CancerCare-PeoriaPeoria, United StatesNo longer taking part
Illinois CancerCare-PeruPeru, United StatesNo longer taking part
Fox Chase Cancer CenterPhiladelphia, United StatesTaking people
Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
Mayo Clinic Hospital in ArizonaPhoenix, United StatesTaking people
Edward Hospital/Cancer Center?PlainfieldPlainfield, United StatesTaking people
UM Sylvester Comprehensive Cancer Center at PlantationPlantation, United StatesTaking people
Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
Hope Cancer CenterPontiac, United StatesNo longer taking part
Kaiser Permanente NorthwestPortland, United StatesTaking people
Oregon Health and Science UniversityPortland, United StatesTaking people
Providence Portland Medical CenterPortland, United StatesTaking people
Providence Saint Vincent Medical CenterPortland, United StatesTaking people
Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
Illinois CancerCare-PrincetonPrinceton, United StatesNo longer taking part
Rhode Island HospitalProvidence, United StatesTaking people
Corewell Health Reed City HospitalReed City, United StatesTaking people
Renown Regional Medical CenterReno, United StatesTaking people
Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
Mayo Clinic in RochesterRochester, United StatesTaking people
University of RochesterRochester, United StatesTaking people
Highlands Oncology Group - RogersRogers, United StatesTaking people
Moffitt Cancer Center at SouthShoreRuskin, United StatesTaking people
Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesTaking people
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
Regions HospitalSaint Paul, United StatesTaking people
United HospitalSaint Paul, United StatesTaking people
Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesTaking people
Salina Regional Health CenterSalina, United StatesTaking people
Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesTaking people
University of Texas Health Science Center at San AntonioSan Antonio, United StatesTaking people
Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
Essentia Health SandstoneSandstone, United StatesTaking people
Saint Francis Regional Medical CenterShakopee, United StatesTaking people
Saint Vincent Hospital Cancer Center at SheboyganSheboygan, United StatesTaking people
Sheboygan Physicians GroupSheboygan, United StatesTaking people
Memorial Hospital EastShiloh, United StatesTaking people
City of Hope South PasadenaSouth Pasadena, United StatesTaking people
Henry Ford Health Providence Southfield HospitalSouthfield, United StatesNo longer taking part
Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesTaking people
Highlands Oncology GroupSpringdale, United StatesTaking people
Southern Illinois University School of MedicineSpringfield, United StatesTaking people
Springfield ClinicSpringfield, United StatesTaking people
Springfield Memorial HospitalSpringfield, United StatesTaking people
Missouri Baptist Medical CenterSt Louis, United StatesTaking people
Siteman Cancer Center at Christian HospitalSt Louis, United StatesTaking people
Siteman Cancer Center-South CountySt Louis, United StatesTaking people
Washington University School of MedicineSt Louis, United StatesTaking people
Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesTaking people
Missouri Baptist Sullivan HospitalSullivan, United StatesTaking people
Moffitt Cancer CenterTampa, United StatesTaking people
Moffitt Cancer Center - McKinley CampusTampa, United StatesTaking people
Moffitt Cancer Center-International PlazaTampa, United StatesTaking people
University of Kansas Health System Saint Francis CampusTopeka, United StatesTaking people
Torrance Memorial Physician Network - Cancer CareTorrance, United StatesTaking people
Munson Medical CenterTraverse City, United StatesTaking people
Banner University Medical Center - TucsonTucson, United StatesTaking people
University of Arizona Cancer Center-North CampusTucson, United StatesTaking people
City of Hope UplandUpland, United StatesTaking people
Carle Cancer CenterUrbana, United StatesTaking people
Northwest Cancer Center - ValparaisoValparaiso, United StatesTaking people
Essentia Health Virginia ClinicVirginia, United StatesTaking people
Illinois CancerCare - WashingtonWashington, United StatesNo longer taking part
Sibley Memorial HospitalWashington D.C., United StatesTaking people
MedStar Georgetown University HospitalWashington D.C., United StatesNo longer taking part
UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
ProHealth Waukesha Memorial HospitalWaukesha, United StatesTaking people
UW Cancer Center at ProHealth CareWaukesha, United StatesTaking people
Wilmot Cancer Institute at WebsterWebster, United StatesTaking people
Moffitt Cancer Center at Wesley ChapelWesley Chapel, United StatesTaking people
Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, United StatesTaking people
Henry Ford West Bloomfield HospitalWest Bloomfield, United StatesTaking people
Marshfield Medical Center - WestonWeston, United StatesTaking people
University of Kansas Hospital-Westwood Cancer CenterWestwood, United StatesTaking people
Asplundh Cancer PavilionWillow Grove, United StatesNo longer taking part
Novant Health Forsyth Medical CenterWinston-Salem, United StatesTaking people
Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
Henry Ford Wyandotte HospitalWyandotte, United StatesTaking people
University of Michigan Health - WestWyoming, United StatesTaking people
UCI Health - Yorba LindaYorba Linda, United StatesTaking people
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people

Questions to ask the study team

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Trial details

Who runs it: National Cancer Institute (NCI)
Trial code: NCT06337318
Record updated: 9 November 2026
Original description: This phase III trial compares the effectiveness of rituximab to mosunetuzumab in treating patients with follicular lymphoma with a low tumor burden. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. It is not yet known if giving rituximab or mosunetuzumab works better in treating patients with follicular lymphoma with a low tumor burden.Read full original descriptionShow less
Randomized Phase III Study of Mosunetuzumab vs. Rituximab for Low Tumor Burden Follicular Lymphoma
This phase III trial compares the effectiveness of rituximab to mosunetuzumab in treating patients with follicular lymphoma with a low tumor burden. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. It is not yet known if giving rituximab or mosunetuzumab works better in treating patients with follicular lymphoma with a low tumor burden.
Inclusion: Participants must have a histologically confirmed diagnosis of classic follicular lymphoma (cFL). cFL was previously categorized as grade 1-3A per World Health Organization (WHO)-HAEM4R, but grading of classic follicular lymphoma (FL) is no longer mandatory; NOTE: Participants with follicular lymphoma with uncommon features (uFL) are eligible, including FL with diffuse growth pattern (dFL). Diagnosis is as per local pathology. Lymphoma fluorescence in situ hybridization (FISH) is not required. Molecular testing is not required; Participants must not have follicular lymphoma with "blastoid" or "large centrocyte" cytological features, or follicular large B-cell lymphoma (FLBL) (previously categorized as follicular lymphoma grade 3B); Participants must have low-tumor burden follicular lymphoma defined as:; Nodal or extra-nodal tumor mass with diameter less than 7 cm in its greater diameter; Involvement of no more than 3 nodal or extra nodal sites with diameter greater than 3 cm; Absence of B symptoms which may include unexplained fever, drenching sweats, unintentional weight loss (more than 10% of body weight); No symptomatic splenomegaly; No compression syndrome (ureteral, orbital, gastrointestinal); No pleural or peritoneal serous effusion related to follicular lymphoma Participants must have Ann Arbor stage II, III, or IV follicular lymphoma. Participants with stage I disease may be included if they do not wish to undergo radiation or are not candidates for radiation; Participants must either be experiencing distress due to their disease or would prefer active management of their disease rather than a watch and wait approach; Participants must have staging imaging performed within 49 days prior to registration, as follows. PET-CT baseline scans are preferred. If a baseline PET-CT scan cannot be obtained, CT scans of the chest, abdomen, and pelvis, along with a bone marrow biopsy, are acceptable. If CT scans are used for staging at baseline, a CT scan of the neck is recommended. All measurable dominant lesions must be assessed within 49 days prior to registration. Tests to assess non-measurable disease must be performed within 49 days prior to registration. All disease must be assessed and documented on the Baseline Tumor Assessment Form; NOTE: if the initial evaluation is insufficient to detect measurable disease, treating investigators may obtain a CT scan with contrast; Participants must have bi-dimensionally measurable disease (at least one lesion with longest diameter > 1.5 cm); Participants must not have had prior systemic therapy for follicular lymphoma. Radiation therapy for a previous diagnosis of early-stage follicular lymphoma is allowed; Participant must be ≥ 18 years of age at the time of registration; Participant must have Zubrod performance status of 0-2; Participant must have a complete medical history and physical exam within 28 days prior to registration; Leukocytes ≥ 3 x 10\^3/uL (within 28 days prior to registration); Hemoglobin > 9.0 g/dL (within 28 days prior to registration); Absolute neutrophil count ≥ 1.5 x 10\^3/uL (within 28 days prior to registration); Platelets ≥ 100 x 10\^3/uL (within 28 days prior to registration); Total bilirubin ≤ 2 x institutional upper limit of normal (ULN) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin ≤ 5 x institutional ULN (within 28 days prior to registration); Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ≤ 3 × institutional ULN (within 28 days prior to registration); Participants must have a calculated creatinine clearance ≥ 30 mL/min using the following Cockcroft-Gault Formula. This specimen must have been collected and processed within 28 days prior to registration; Participants must not have an active or uncontrolled infection before initiation of study treatment in the opinion of the treating investigators; Participants must not have uncontrolled diabetes within 14 days prior to registration in the opinion of the treating investigators; Participants must not have uncontrolled blood pressure and hypertension within 14 days prior to registration in the opinion of the treating investigators; Participants with known human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy at registration and have undetectable viral load test on the most recent test results obtained within 6 months prior to registration; Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load while on suppressive therapy on the most recent test results obtained within 6 months prior to registration, if indicated. Participants with a positive total hepatitis (Hep) B core antibody and negative hepatitis B virus surface antigen (HBsAg) at screening are at high risk for reactivation and should receive prophylactic antivirals (e.g., entecavir) before and throughout the treatment; Participants must not have autoimmune disease requiring systemic immunosuppressive therapy; Participants must not have had undergone organ transplants requiring ongoing systemic immunosuppressive therapy; Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants currently being treated for HCV infection must have undetectable HCV viral load test on the most recent test results obtained within 6 months prior to registration, if indicated; Participants must not have known chronic active Epstein Barr Virus infection (CAEBV); testing in asymptomatic participants is not required; Participants must not have a positive test result for COVID-19 within seven (7) days prior to registration; Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen; Participants must not have a history of confirmed progressive multifocal leukoencephalopathy (PML); Participants must not have received allogeneic stem cell transplantation; Participants must not have a history of macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH); Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. Participant must not have significant cardiovascular disease such as class III or IV cardiac disease, myocardial infarction within 6 months prior to registration. Participants with unstable arrhythmias, or unstable angina, should be excluded; Participants must not be pregnant or nursing (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped). Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen; Participants registered by participating United States (U.S.) sites must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System; NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system; Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines; For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations.
ClinicalTrials.gov NCT06337318