Norepinephrine for Low Blood Pressure During Surgery in Heart Failure Patients
Observes how a diluted norepinephrine dose affects heart output in adults with heart failure.
Key facts
- Who runs it
- University Hospital, Toulouse
- Where
- Toulouse, FranceSee the site
- Trial code
- Registry title
- Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients
- Status
- Recruiting
- People taking part
- 50 people, planned
- Started
- 17 Oct 2024
- Expected to end
- Dec 2026
- Type of study
- Observational
- Treatments tested
- Cardiac output monitoring by the Starling™ SV Sebac®
- Record updated
- 5 November 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with long-term heart failure who have low blood pressure after going under general anesthesia, before surgery starts.
- Age
- 18 years and older
- Sex
- All sexes can join.
- Disease stage
- Left-sided heart failure with an ejection fraction of 40% or less, measured by echocardiography less than a year ago. Low blood pressure must appear after anesthesia induction and before surgical stimulation.
- Earlier treatment
- Must be on heart failure treatment adapted to the level of heart failure, following the 2021 European Society of Cardiology recommendations. Must not have been treated with catecholamines before the procedure.
Main reasons for not taking part
- Right-sided heart failure
- Acute pulmonary edema, pulmonary arterial hypertension, severe valve disease or a hole between heart chambers (intracardiac shunt)
- Heart rhythm problems (supraventricular or ventricular arrhythmia)
- Urgent surgery
- Pregnant or breastfeeding women
The registry criteria, word for word
Show all 20 criteriaShow less
Who can take part
- Adult patients
- Heart failure patients with left ventricular failure with a ventricular ejection fraction less than or equal to 40% evaluated by trans-thoracic echocardiography less than a year ago and specifying in particular the patient's filling pressures at the state stable
- Patients under treatment adapted to the level of heart failure according to the 2021 European Society of Cardiology recommendations
- Scheduled surgery under general anesthesia
- Invasive hemodynamic monitoring planned by the anesthetist-resuscitator (irrespective of potential inclusion in the protocol): arterial catheter and central venous line for measurement of CVP (central venous pressure)
- Postoperative monitoring planned in intensive care or intensive care
- Presence of controlled mechanical ventilation with tidal volumes between 8 and 10 ml/kg of ideal weight
- Presence of arterial hypotension after induction of general anesthesia, and before surgical stimulation
- Patient affiliated to a social security scheme or equivalent
- No opposition from the patient
Who cannot take part
- Patients treated with catecholamines prior to the procedure
- Chronic heart failure patients with right ventricular failure
- Patients presenting signs of acute pulmonary edema, Pulmonary arterial hypertension (PAH), severe valvular disease, intracardiac shunt
- Patients with respiratory compliance disorders with compliances greater than 30 cm of water
- Patients with intra-abdominal hypertension
- Patients with supraventricular or ventricular arrhythmia
- Patients operated on under general anesthesia but maintaining spontaneous ventilation
- Patients operated on for urgent surgeries
- Patient under guardianship, curatorship or safeguard of justice
- Pregnant or breastfeeding women
Where in France
- CHU Toulouse-RangueilToulouse, FranceContact: François LABASTE, DrTaking people
About the trial
What the trial wants to find out
Arterial hypotension is a frequent complication of general anesthesia and a significant contributor to postoperative complications. It is a critical marker for the development of acute renal failure and postoperative myocardial infarction. Chronic heart failure (CHF) patients are increasingly encountered in the operating room, and their perioperative morbidity and mortality are substantial, with specific management lacking precise recommendations.
Read full original descriptionShow less
The main objective is to assess the impact of a diluted norepinephrine bolus on cardiac output in chronic heart failure patients experiencing arterial hypotension after anesthesia induction.
The group in the trial
- Research procedures
Patients with heart failure
Treatment: Cardiac output monitoring by the Starling™ SV Sebac®
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients in the Operating Room.
- Plain-language title
- Norepinephrine for Low Blood Pressure During Surgery in Heart Failure PatientsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 5 November 2026