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Testing blood pressure control after clot removal in acute ischemic stroke

Compares conservative, moderate and intensive blood pressure control in adults after stroke clot removal.

Key facts

Who runs it
The George Institute
Where
Calgary, CanadaSee the siteAlso in 1 other country, 1 site
Trial code
Registry title
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial
Status
Recruiting
People taking part
2,000 people, planned
Started
11 Oct 2024
Expected to end
May 2028
Type of study
Interventional, 3 groups
Treatments tested
  • Conservative SBP Control
  • Moderate SBP Control
  • Intensive SBP Control
Record updated
8 July 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who have had a stroke from a blocked brain artery, were treated to remove the clot, and then have high blood pressure. It tests three ways of lowering blood pressure.

Age
18 years or older.
Sex
All sexes can join.
Disease stage
Sudden stroke from a blocked brain artery, treated with endovascular therapy (clot removal through a blood vessel) within 24 hours of symptom onset or last known well.
Earlier treatment
Must have had endovascular therapy (EVT) within 24 hours of symptom onset or last known well, following local guidelines.
Biomarker or test result
Systolic blood pressure of 150 mmHg or higher, on 2 readings less than 10 minutes apart, within 3 hours after the end of EVT.

Main reasons for not taking part

  • Any clear reason why blood pressure lowering treatment cannot be used

The registry criteria, word for word

Show all 4 criteriaShow less

Who can take part

  • Age ≥18 years
  • Use of endovascular therapy (EVT) within 24 hours of symptom onset or last known well according to local guidelines
  • Sustained high systolic blood pressure ≥150 mmHg (2 readings <10 mins apart) within 3 hours after completion of EVT

Who cannot take part

  • 1.Any definite contraindications to BP lowering treatment

Where in Canada

Also in 1 other country, 1 site

  • University Of CalgaryCalgary, CanadaContact: Carol C Kenney, RNTaking people

About the trial

What the trial wants to find out

Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients. Although two trials indicate harm from very intensive target-based treatment (SBP <130 mmHg), the others neutral effects in the SBP range 140-160 mmHg. The ENCHANTED3/MT domain of the ACT-GLOBAL platform trial aims to test different approaches to the treatment of elevated SBP in post-EVT AIS patients to find an optimal BP management strategy. ENCHANTED3/MT will randomize (1:1:1) up to 2,000 patients with SBP ≥150 mmHg post-EVT to conservative (no or minimal SBP reduction by 5-10mmHg or a target of 175-180mmHg if very-high baseline SBP [≥180mmHg]), moderate (SBP reduction by 10-20mmHg or a target of 160 ± 5, whichever is higher; no control if low-high baseline SBP [150-160mmHg]), or intensive (SBP reduction by 30-50mmHg or a target of 140±5 mmHg, whichever is higher) BP management.

The 3 groups in the trial

  • Conservative SBP ControlTreatment being tested
  • Moderate SBP ControlTreatment being tested
  • Intensive SBP ControlTreatment being tested

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within A Multi-faCtorial, mulTi-arm, Multi-staGe, Randomised, gLOBal Adaptive pLatform Trial for Stroke (ACT-GLOBAL_ENCHANTED3/MT)
Plain-language title
Testing blood pressure control after clot removal in acute ischemic strokeGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
8 July 2026