Studies how tuberculosis infection may affect the placenta during pregnancy
Compares placentas and births of pregnant women with and without tuberculosis infection.
Plain-language title generated from the registry record
Registry title: Effects of Tuberculosis Infection on Development and Function of the Placenta
Key facts
- Where
- Addis Ababa, EthiopiaSee the site
Where in Ethiopia
- Gandhi Memorial HospitalAddis Ababa, EthiopiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Lund University
- Trial code
- NCT06352970
- Record updated
- 3 September 2026
- Original description
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta.Read full original descriptionShow less
Effects of Tuberculosis Infection on Placental Development and Function
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta.
The main questions it aims to answer are:
* Does TB infection affect the structure of the placenta? * Does TB infection affect the function of the placenta?
Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection:
* Pathological lesions of the placenta * Gene and protein expression patterns linked to pregnancy-related disorders * Infant outcome at birth and at 6 weeks after birth
Inclusion: Women admitted for delivery to study sites; Written informed consent; Age 18 years or greater.
Exclusion: Chronic comorbidities (other than TB, HIV or pregnancy-related disorder); Twin pregnancy.