Brain wave recording study in hard-to-treat epilepsy and rare genetic syndromes
Records brain electrical activity with EEG in people with epilepsy or rare syndromes.
Plain-language title generated from the registry record
Registry title: Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Key facts
- Where
- Conegliano, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 75 years old?
Source: NCT06353620, who can take part
Where in Italy
- IRCCS E. MedeaConegliano, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS Eugenio Medea
- Trial code
- NCT06353620
- Record updated
- 9 April 2024
- Original description
Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks. Indeed, this has helped to identify functionally altered areas in patients with temporal epilepsy by simply using the resting EEG signal. Furthermore, it has been seen that the propagation of neuronal avalanches (VNs) correlates with the morphological organization of the cerebral cortex. Therefore, NAs represent a measure with direct utility for studying functional reorganization pre and post drug/surgical treatment. In addition, the aperiodic portion of the signal may represent a noninvasive measure of the excitation/inhibition relationship, which is known of being altered both in epilepsy and in some rare neurodevelopmental syndromes (example: Angelman and Dup15q)Read full original descriptionShow less
Structural-functional Connectome With High-density Electroencephalography in Drug-resistant Epilepsies and Rare Neurodevelopmental Syndromes With Epilepsy
Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks. Indeed, this has helped to identify functionally altered areas in patients with temporal epilepsy by simply using the resting EEG signal. Furthermore, it has been seen that the propagation of neuronal avalanches (VNs) correlates with the morphological organization of the cerebral cortex. Therefore, NAs represent a measure with direct utility for studying functional reorganization pre and post drug/surgical treatment. In addition, the aperiodic portion of the signal may represent a noninvasive measure of the excitation/inhibition relationship, which is known of being altered both in epilepsy and in some rare neurodevelopmental syndromes (example: Angelman and Dup15q)
Inclusion: a diagnosis of focal or generalized epilepsy, Angelman syndrome, or Dup15q, confirmed by specialist evaluation; at least one MRI scan of the brain that includes 3D T1 sequences; at least one 128-channel HD-EEG recording; and; age between 6 and 75 years at the time of the evaluation of the present study; ability to take part in a neuropsychological evaluation.
Exclusion: vascular causes or non-low-grade tumors as causes of epilepsy; age different from the range 6-75 years; neuroradiological examination not complete (absence T1 3D); absence of HD-EEG 128-channel recording; inability to take part in a neuropsychological evaluation.