NCT06354933Completed
Neurological Soft Signs in Neurodegenerative Dementias
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
The goal of this observational study is to investigate the prevalence of Neurological Soft Signs (NSS) in various categories of dementia patients compared to matched controls. The main questions it aims to answer are: * Does the prevalence of NSS significantly differ among patients with neurodegenerative dementias compared to controls? * Are NSS associated with neuropsychiatric alterations in dementia patients? * Do NSS correlate with cognitive screening tools? * Do NSS increase over time in patients with neurodegenerative dementias? Participants will undergo assessments including: * Evaluation of NSS using the Heidelberg scale * Neuropsychiatric assessments * Cognitive screening using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) Researchers will compare dementia groups (Alzheimer's disease, Frontotemporal dementia, Corticobasal syndrome and Lewy body dementia) to controls to determine differences in NSS prevalence. Additionally, associations between NSS and neuropsychiatric symptoms, as well as cognitive performance, will be explored.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 186 (actual)
- First submitted
- 3 Apr 2024
- Start date
- 1 Apr 2022
- Primary completion date
- 30 Nov 2023
- Lead sponsor
- University of Milano Bicocca
- NCT number
- NCT06354933
What you commit to
- Study type: Observational
- Participants enrolled: 186
- From 1 Apr 2022 to the primary completion date, 30 Nov 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Mixed dementia or vascular etiology.
- History of neurological or psychiatric conditions predating the dementia diagnosis.
- Known comorbidities affecting neurological or psychiatric function.
Other
- Substance or alcohol abuse history.
- MMSE score less than or equal to 10.
- Inability to provide informed consent.
Who the study is looking for
- Diagnosis of probable Alzheimer's Disease (AD), Frontotemporal Dementia (FTD), Corticobasal Syndrome (CBS), or probable Lewy Body Dementia (LBD) according to established clinical criteria.
- MMSE score greater than 10.
- Age and gender-matched controls without a history of neurological or psychiatric conditions.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione IRCCS San Gerardo dei Tintori Coordinator of this site? Confirm its status | Monza | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.