NCT06364163Active, not recruiting
Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults
A Study on the Effect of Consuming a Herring Oil Concentrate on LDL Cholesterol Concentration in Adults With Overweight or Obesity
Source: ClinicalTrials.gov · Last updated 2 Oct 2025
Brief summary (registry, in English)
High cholesterol concentration is a major risk factor for cardiovascular disease (CVD), and consumption of fish has been associated with a lower CVD risk in several studies. The beneficial health effects of consuming fish have traditionally been ascribed to the long-chain PUFA (LC-PUFA) EPA (C20:5n-3) and DHA (C22:6n-3), although consumption of fish oils or concentrates with high EPA and DHA contents does not affect the cholesterol concentration in humans and lowers the cholesterol concentration in rats and mice only when given in very high doses. Fish oils contain a plethora of fatty acids besides EPA and DHA, and in recent years, increased focus has been on the long-chain MUFA (LC-MUFA) cetoleic acid (C22:1n-11). Cetoleic acid is found in high amounts in oils from certain fish species such as herring, which has relatively low contents of both EPA and DHA. The investigators have recently summarised and meta-analysed the available literature that investigates the effects of diets containing fish oils or fish oil concentrates that have a high content of cetoleic acid but low or no content of EPA and DHA on cholesterol concentration in rodents, showing that cetoleic acid-rich fish oils and concentrates prevent high cholesterol concentration.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 80 (actual)
- First submitted
- 6 Apr 2024
- Start date
- 12 Aug 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Bergen
- Diseases
- Obesity, Familial hypercholesterolaemia
- NCT number
- NCT06364163
What you commit to
- Study type: Interventional
- Participants enrolled: 80
- From 12 Aug 2024 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Had bariatric surgery or using medications for weight loss
- Recent or planned surgical procedures
Other illness
- Allergies towards fish, milk, egg, gluten
- Diseases affecting the heart, intestinal function, kidney function or insulin secretion
Lab values
- Use of medications targeting cholesterol -or glucose metabolism
Other
- Tobacco use (cigarettes or snus)
- Use of dietary supplements
- Pregnant or breastfeeding
- Following a strict diet
- High intake of fish/seafood
Who the study is looking for
- BMI over 25 kg/m2
- Stable body weight last 3 months
Age in the registry: 20 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Bergen Coordinator of this site? Confirm its status | Bergen | Norway | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.