Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia

The registry criteria, word for word

What the trial wants to find out

This study aims to assess whether administering intravenous iron early in pregnancy, compared to standard oral iron treatment, can enhance hemoglobin levels before delivery and reduce the need for blood transfusions in patients with iron deficiency anemia. Patients diagnosed with iron deficiency anemia were randomly assigned to receive either oral or intravenous iron. Before treatment initiation, patients completed a symptom questionnaire baseline hemoglobin, and ferritin levels were measured. Follow-up visits occurred four weeks later and at 24 to 28 weeks gestation, involving reassessment of symptoms, laboratory testing, and monitoring of treatment adherence. Final hemoglobin levels were determined before delivery, and data on the need for blood transfusion at delivery were recorded.

The 2 groups in the trial

• Intravenous ironExisting treatment, for comparison

  Venofer 200 mg will be given every other day until the patient reaches their calculated in deficit dose. The does of IV iron will be calculated according to the Ganzoni formula: total iron dose (mg) = body weight (kg) x (target Hgb - baseline Hgb (g/dL)) × 0.24 + 500 mg.14 Our target Hgb will be 11.0 g/dL. The determination of the treatment duration and dosage will be based on the calculation of the iron deficit.

  Treatment: Venofer 200 MG Per 10 ML Injection

• Oral ironPlacebo, for comparison

  Ferrous sulfate 325 mg orally every other day on an empty stomach with lemon/orange water until delivery.

  Treatment: Ferrous sulfate