Under construction – not a live service
Sign in
Taking people in GermanyNo phase

Tests shockwave lithotripsy during stent placement for calcified coronary artery narrowing

Compares shockwave treatment with standard methods to open hardened blockages in heart arteries.

Plain-language title generated from the registry record
Registry title: Intracoronary Stenting and Additional Results Achieved by ShockWAVE Coronary Lithotripsy

Key facts

Where
Augsburg, Bad Oeynhausen, Bad Oldesloe, Berlin, Dachau, Dresden, Erding, Essen, Hamburg, Heidelberg, Ingolstadt, Landshut, Mannheim, München, Munich, Rotenburg an der Fulda, Singen, Trier, and Ulm, GermanySee the 22 sites

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with coronary artery disease who have a new, severely calcified narrowing in a native heart artery and need stenting.

Age
18 years or older
Sex
Men and women
Disease stage
Coronary artery disease with typical angina or proven ischemia on optimal drug therapy. A new (de novo) lesion in a native coronary artery, severely calcified (angiographic grade 3), in a vessel 2.5-4 mm wide.
Earlier treatment
Must be on optimal drug therapy.

Main reasons for not taking part

  • Heart attack less than 1 week ago
  • Blood clot (thrombus) in the target vessel
  • Life expectancy under 1 year because of another disease
  • Taking part in another unfinished trial of a device or medicine
  • Pregnancy (current, suspected or planned) or a positive pregnancy test

Read by machine on 12 November 2026.

Where in Germany

  • Universitätsklinikum Augsburg A.ö.RAugsburg, GermanyContact: Dario Bongiovanni, Prof. Dr. med., PhDTaking people
  • Herz- und Diabeteszentrum Nordrhein-WestfalenBad Oeynhausen, GermanyContact: Mohamed Ayoub, Dr. med.Taking people
  • Asklepios Klinik Bad Oldesloe Innere Medizin, Kardiologie und IntensivmedizinBad Oldesloe, GermanyContact: Ralph Tölg, PD Dr. med.Taking people
  • BG Klinikum Unfallkrankenhaus Berlin gGmbHBerlin, GermanyContact: Johannes Beil, Dr. med.Taking people
  • Klinik für Kardiologie, Angiologie und Intensivmedizin Deutsches Herzzentrum der CharitéBerlin, GermanyContact: Damaris Praeger, Dr. med.Taking people
  • Helios Amper-Klinikum Dachau, Kardiologie und PneumologieDachau, GermanyContact: Bernhard Witzenbichler, PD Dr. med.Taking people
  • Herzzentrum Dresden GmbH Universitätsklinik an der Technischen Universität DresdenDresden, GermanyContact: Salvatore Cassese, MD, PHDNo longer taking part
  • Klinikum Landkreis ErdingErding, GermanyContact: Lorenz Bott-Flügel, PD Dr. med.Taking people
  • Elisabeth Krankenhaus Essen Contilia Herz- und Gefäßzentrum Klinik für Kardiologie und Angiologie Kardiovaskuläres StudienzentrumEssen, GermanyContact: Tobias Weinreich, Dr. med.Taking people
  • Universitäres Herz- und GefäßzentrumHamburg, GermanyContact: Fabian Brunner, PD Dr. med.Taking people
  • Universitätsklinikum Heidelberg, Klinik für Kardiologie, Angiologie und PneumologieHeidelberg, GermanyContact: Salvatore Cassese, MD, PHDNo longer taking part
  • Klinikum IngolstadtIngolstadt, GermanyContact: Blerim Luani, PD Dr. med.Taking people
  • Krankenhaus Landshut-Achdorf, LAKUMED KlinikenLandshut, GermanyContact: Julinda Mehilli, Prof. Dr. med.Taking people
  • Universitätsklinikum Mannheim GmbH, I. Medizinische Klinik, Kardiologie, Angiologie, Hämostaseologie, Internistische IntensivmedizinMannheim, GermanyContact: Ibrahim Akin, Prof. Dr. med.Taking people
  • Augustinum Klinik MünchenMünchen, GermanyContact: Oliver Husser, Prof. Dr. med.Taking people
  • Klinikum der Ludwig-Maximilians-Universität MünchenMünchen, GermanyContact: Konstantinos Rizas, Prof. Dr. med.Not yet recruiting
  • Deutsches Herzzentrum MünchenMunich, GermanyContact: Salvatore Cassese, PD, PHDTaking people
  • Klinikum Hersfeld Rotenburg GmbH Herz-Kreislauf-Zentrum Institut für Klinische ForschungRotenburg an der Fulda, GermanyContact: Marcus Franz, Prof. Dr. med.Taking people
  • Hegau-Bodensee-Klinikum Singen GmbH, I. Medizinsche Klinik (Kardiologie und internistische Intensivmedizin)Singen, GermanyContact: Marc Kollum, PD Dr. med.Taking people
  • Krankenhaus Barmherzige Brüder TrierTrier, GermanyContact: Nikos Werner, Prof. Dr. med.Taking people
  • Universitätsklinikum UlmUlm, GermanyContact: Wolfgang Rottbauer, Prof. Dr. med.Taking people
  • Cardiologikum Herzklinik Ulm MVZUlm, GermanyContact: Salvatore Cassese, MD, PHDNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Deutsches Herzzentrum Muenchen
Trial code
NCT06369142
Record updated
6 January 2026
Original description
The clinical trial is intended to evaluate the efficacy, safety and economic benefit of coronary lithotripsy compared to other additional procedures (cutting or super high pressure balloon angioplasty, ablative procedures) in lesion preparation and interventional treatment of severely calcified coronary stenoses.Read full original descriptionShow less

Intracoronary Stenting and Additional Results Achieved by ShockWAVE Coronary Lithotripsy: A Randomized, Multicenter Study About the Additional Benefit of Coronary Lithotripsy

The clinical trial is intended to evaluate the efficacy, safety and economic benefit of coronary lithotripsy compared to other additional procedures (cutting or super high pressure balloon angioplasty, ablative procedures) in lesion preparation and interventional treatment of severely calcified coronary stenoses.

Inclusion: age ≥18 years and able to give informed consent; written informed consent to participate in the clinical trial; typical angina pectoris or non-invasive evidence of relevant ischemia under optimal drug therapy; angiographic evidence of coronary artery disease; de novo lesion in a native coronary artery; target vessel diameter 2.5-4 mm; severe calcification of the target lesion (angiographic grade 3).

Exclusion: myocardial infarction <1 week; life expectancy due to other disease <1 year; thrombus in the target vessel; simultaneous participation in a clinical trial with medical devices or medicinal products that has not yet been completed; pregnancy (current, suspected, planned) or positive pregnancy test.

ClinicalTrials.gov NCT06369142