Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints
Key facts
- Where
- Malmö, SwedenSee the 2 sites
Where in Sweden
- Aleris Specialistläkare HyllieMalmö, SwedenContact: My Winblad von Walter, MDTaking people
- Department of Hand Surgery, Skane University HospitalMalmö, SwedenContact: Elisabeth Brogren, MD, PhDNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Region Skane
- Trial code
- NCT06370312
- Record updated
- 25 June 2025
- Original description
The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid.Read full original descriptionShow less
Analysis of Synovial Fluid, Bone and Articular Cartilage From Osteoarthritic First Carpometacarpal Joints in Relationship to Metabolic Risk Factors and Patient-reported Hand Function
The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid.
Inclusion: Men and women age ≥ 25 years; Radiologically confirmed and symptomatic thumb basal joint osteoarthritis (OA) planned for trapeziectomy.
Exclusion: Previous surgery to the affected thumb basal joint; Rheumatoid arthritis or other chronic inflammatory arthritis, history of psoriasis affecting joints, gout or pseudogout; Ongoing infection in the hand or wrist; Inability to co-operate with the follow-up protocol or to assimilate information about the study protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction); Systemic or intra-articular glucocorticoids or intraarticular platelet-rich plasma or hyaluronic acid injections in the affected joint within 3 months prior to enrollment; Post-traumatic thumb basal joint OA.