Tests whether an inhaled natural odour reaches spinal fluid in people with obesity
Tests an inhaled natural odour in adults with overweight or obesity, and in lean adults.
Plain-language title generated from the registry record
Registry title: ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study
Key facts
- Where
- Basel, SwitzerlandSee the 2 sites
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT06370845, who can take part
Where in Switzerland
- University Hospital BaselBasel, SwitzerlandNot yet recruiting
- University Hospital of BaselBasel, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Basel, Switzerland
- Trial code
- NCT06370845
- Record updated
- 4 May 2026
- Original description
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.Read full original descriptionShow less
Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure - the OLFO-Brain Study
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.
Inclusion: Age 18-60 years; Written informed consent; Scheduled for routine liquor puncture; BMI ≥ 30 kg/m2; No proven diagnose of diabetes; Age 18-60 years; Written informed consent; Scheduled for routine liquor puncture; BMI 18-25 kg/m2.
Exclusion: Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain; Known allergy to the natural odour; Acute upper respiratory tract infection, acute or chronic sinusitis; Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate <30 ml/min/m2); Pregnancy/lactation; Inability to understand the study procedure and to sign the study consent.