Looking for early signs of a kidney blockage in young children
Studies urine and blood tests to find markers of a kidney blockage in babies.
Plain-language title generated from the registry record
Registry title: The PRO-FUTURE Project
Key facts
- Where
- Milan, Modena, and Naples, ItalySee the 5 sites
Where in Italy
- Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoMilan, ItalyTaking people
- Department of Clinical Sciences and Community Health, University of MilanoMilan, ItalyNo longer taking part
- Obstetrics and Gynecology Unit, University of Modena and Reggio EmiliaModena, ItalyTaking people
- Aorn Santobono PausiliponNaples, ItalyTaking people
- Univeristà degli Studi della Campania Luigi VanvitelliNaples, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Campania Luigi Vanvitelli
- Trial code
- NCT06382233
- Record updated
- 30 April 2024
- Original description
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:Read full original descriptionShow less
PRecocious biOmarkers oF Unilateral ureTero-pelvic jUnction obstRuction in childrEn
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:
* Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?
Inclusion: unilateral UPJO; 0-5years of age.
Exclusion: previous surgical intervention on the urinary tract; urinary tract infections; bilateral UPJO; bladder or lower urinary tract symptoms or malformations; nephro- or urolithiasis, vesicoureteral reflux.