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Taking people in ItalyNo phase

Looking for early signs of a kidney blockage in young children

Studies urine and blood tests to find markers of a kidney blockage in babies.

Plain-language title generated from the registry record
Registry title: The PRO-FUTURE Project

Key facts

Where
Milan, Modena, and Naples, ItalySee the 5 sites

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for babies and children up to 5 years old with a blockage where the kidney meets the ureter (unilateral ureteropelvic junction obstruction) on one side only.

Age
From 1 Day to 5 Years
Sex
All sexes can join.
Disease stage
Unilateral ureteropelvic junction obstruction (UPJO), meaning a blockage on one side only.
Earlier treatment
No previous surgery on the urinary tract.

Main reasons for not taking part

  • Blockage on both sides (bilateral UPJO)
  • Previous surgery on the urinary tract
  • Bladder or lower urinary tract symptoms or malformations
  • Kidney or urinary stones, or vesicoureteral reflux
  • Urinary tract infections

Read by machine on 12 November 2026.

Where in Italy

  • Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoMilan, ItalyContact: Giovanni MontiniTaking people
  • Department of Clinical Sciences and Community Health, University of MilanoMilan, ItalyContact: Pierluigi Marzuillo, MD PhDNo longer taking part
  • Obstetrics and Gynecology Unit, University of Modena and Reggio EmiliaModena, ItalyContact: Giovanni GrandiTaking people
  • Aorn Santobono PausiliponNaples, ItalyContact: Giovanni Di IorioTaking people
  • Univeristà degli Studi della Campania Luigi VanvitelliNaples, ItalyContact: Pierluigi MarzuilloTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
University of Campania Luigi Vanvitelli
Trial code
NCT06382233
Record updated
30 April 2024
Original description
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:Read full original descriptionShow less

PRecocious biOmarkers oF Unilateral ureTero-pelvic jUnction obstRuction in childrEn

The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:

* Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?

Inclusion: unilateral UPJO; 0-5years of age.

Exclusion: previous surgical intervention on the urinary tract; urinary tract infections; bilateral UPJO; bladder or lower urinary tract symptoms or malformations; nephro- or urolithiasis, vesicoureteral reflux.

ClinicalTrials.gov NCT06382233