Tracks recovery and limb function after upfront surgery for bone cancer
Follows young people with bone cancer in a limb through questionnaires after surgery.
Plain-language title generated from the registry record
Registry title: Upfront Surgical Resection for Osteosarcoma
Key facts
- Where
- The Bronx, United StatesSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 5 to 40 with newly diagnosed osteosarcoma of an arm or leg who plan to have surgery first, before any chemotherapy.
- Age
- 5 Years to 40 Years
- Sex
- All sexes can join.
- Disease stage
- Newly diagnosed, localized, high-grade osteosarcoma of an arm or leg, confirmed by tissue examination (histopathology).
- Earlier treatment
- No earlier treatment for the tumor. Surgery to remove the tumor is planned first, followed by chemotherapy. Systemic therapy must not have started before joining. No prior radiation therapy.
Main reasons for not taking part
- Cancer that has spread at diagnosis
- Systemic therapy started before joining
- Earlier history of cancer
- Earlier radiation therapy
- Active life-threatening infection
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 5 and 40 years old?
Source: NCT06384404, who can take part
Where in United States
- Montefiore Medical CenterThe Bronx, United StatesContact: Rebecca ZylberTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Montefiore Medical Center
- Trial code
- NCT06384404
- Record updated
- 16 March 2026
- Original description
The goal of this pilot study is to learn about patients with newly diagnosed osteosarcoma of an extremity, and whether surgically removing the tumor prior to the administration of any chemotherapy will improve functional outcomes. In order to learn about the patient's experience, the study team will administer questionnaires to the patient and surgeon at various timepoints to assess recovery and the function of the extremity.Read full original descriptionShow less
Functional Outcomes in Patients Who Undergo Upfront Surgical Resection for High-Grade Osteosarcoma of the Extremity: A Pilot Study
The goal of this pilot study is to learn about patients with newly diagnosed osteosarcoma of an extremity, and whether surgically removing the tumor prior to the administration of any chemotherapy will improve functional outcomes. In order to learn about the patient's experience, the study team will administer questionnaires to the patient and surgeon at various timepoints to assess recovery and the function of the extremity.
Inclusion: Patients must have newly diagnosed, previously untreated, localized, high-grade osteosarcoma of an extremity (verified by histopathology) with plans to undergo upfront surgical resection of the tumor followed by systemic chemotherapy; Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2 (Karnofsky will be used for patients >16 years of age and Lansky score for patients <= 16 years of age).
Exclusion: Initiation of systemic therapy prior to enrollment; Prior radiation therapy; Patients with metastatic disease at diagnosis; Prior history of cancer; Active life-threatening infection; Pregnancy (negative pregnancy test result must be obtained for female patients of childbearing potential).