NCT06390306Recruiting
The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBP
The Efficacy and Safety of Third Generation Tyrosine Kinase Inhibitors Combined With Azacitidine and B-cell Lymphoma-2 Inhibitor in Patients With Myeloid Blast Phase Chronic Myeloid Leukemia
Source: ClinicalTrials.gov · Last updated 3 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a prospective multi-center study to investigate efficacy and safety of the third generation tyrosine kinase inhibitors (TKIs) combined with azacitidine and B-cell lymphoma-2 (Bcl-2) inhibitor in patients with myeloid blast phase chronic myeloid leukemia (CML-MBP).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 18 Apr 2024
- Start date
- 1 Jul 2024
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Peking University People's Hospital
- Diseases
- Chronic myeloid leukaemia
- NCT number
- NCT06390306
What you commit to
- Study type: Observational
- Planned participants: 30
- From 1 Jul 2024 to the primary completion date, 1 Dec 2026
- 15 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- concurrent diseases requiring treatment(s) with potential to interact with 3G-TKI;
Other illness
- diagnosis of other primary malignancies;
- history of allogeneic HSCT;
- extramedullary disease only.
Who the study is looking for
- age ≥ 18 years old;
- philadelphia chromosome (Ph)-positive or BCR::ABL-positive;
- serum creatinine ≤ 1.5 × upper limit of normal (ULN) or 24h creatinine clearance ≥ 50 mL/min when serum creatinine was \> 1.5 × ULN;
- serum total bilirubin ≤ 1.5 × ULN;
- aspartate aminotransferase and alanine aminotransferase ≤ 2.5 × ULN;
- amylase ≤ 1.5 × ULN; (7) lipase ≤ 1.5 × ULN;
- ejection fraction \> 50%; corrected QT interval on electrocardiographic evaluation was ≤ 450 ms in men or ≤ 470 ms in women.
Age in the registry: 18 years to - · Sex: All
Sites (15)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chuiyangliu hospital affiliated to tsinghua university Coordinator of this site? Confirm its status | Beijing | China | Not yet recruiting |
| Peking University People's Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| Beijing Lu Daopei Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| Sichuan Provincial People's Hospital Coordinator of this site? Confirm its status | Chengdu | China | Not yet recruiting |
| Nanfang Hospital, Southern Medical University Coordinator of this site? Confirm its status | Guangdong | China | Not yet recruiting |
| The First Affiliated Hospital of Kunming Medical University Coordinator of this site? Confirm its status | Kunming | China | Not yet recruiting |
| The First Affiliated Hospital of Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
| The First Affiliated Hospital of Guangxi Medical University Coordinator of this site? Confirm its status | Nanning | China | Recruiting |
| Nanyang Central Hospital Coordinator of this site? Confirm its status | Nanyang | China | Recruiting |
| Ningbo Medical Center Lihuili Hospital Coordinator of this site? Confirm its status | Ningbo | China | Recruiting |
| Qilu Hospital of Shandong University Coordinator of this site? Confirm its status | Qilu | China | Not yet recruiting |
| Chinese Academy of Medical Sciences & Peking Union Medical College Hospital Coordinator of this site? Confirm its status | Tianjin | China | Not yet recruiting |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Henan Cancer Hospital Coordinator of this site? Confirm its status | Wuhan | China | Not yet recruiting |
| Xi'an International Medical Center Hospital Coordinator of this site? Confirm its status | Xi'an | China | Recruiting |
| The First Affiliated Hospital, Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Zhejiang | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.