Tests focused ultrasound to aid movement recovery after stroke
Tests focused ultrasound on the brain in adults recovering from stroke.
Plain-language title generated from the registry record
Registry title: Neuromodulation Effect of Focused Ultrasound for Motor Recovery in Patients With Stroke
Key facts
- Where
- Taipei, TaiwanSee the site
Where in Taiwan
- National Taiwan University HospitalTaipei, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT06391086
- Record updated
- 13 April 2026
- Original description
Transcranial focused ultrasound (tFUS) can be used as a non-invasive brain neuromodulation technique. Low-intensity focused ultrasound has been demonstrated to be safe and have neuromodulatory effects on the cerebral cortex in healthy human and animal experiments.This study aims to investigate the effect of tFUS on cortical excitability for motor recovery in patients with stroke.Read full original descriptionShow less
Neuromodulation Effect of Focused Ultrasound for Motor Recovery in Patients With Stroke
Transcranial focused ultrasound (tFUS) can be used as a non-invasive brain neuromodulation technique. Low-intensity focused ultrasound has been demonstrated to be safe and have neuromodulatory effects on the cerebral cortex in healthy human and animal experiments.This study aims to investigate the effect of tFUS on cortical excitability for motor recovery in patients with stroke.
Inclusion: Patients with stroke (including hemorrhagic or ischemic stroke) diagnosed by a board-certificated physician; Occurrence of stroke within three months; Upper limb muscle strength ≤ 4 points according to the Medical Research Council Manual Muscle Testing scale; No previous history of stroke, epilepsy, dementia, Parkinson's disease, or other neurodegenerative diseases; Patients could maintain sitting posture for more than 15 minutes on a chair; 18 years of age or older.
Exclusion: Patients with metallic implants in their bodies; Patients taking tricyclic antidepressants, analgesics, or using antiepileptic drugs; History of recurrent stroke, traumatic brain injuries, brain tumors, spinal cord injury, Parkinson's disease or other musculoskeletal system diseases that may affect evaluation and treatment; Major physical illnesses and neurological disorders (such as epilepsy, brain surgery, etc.); Individuals experiencing sleep disorders during tFUS treatment; Individuals with history of alcoholism; Contraindications to focused ultrasound, including pregnancy, cardiac pacemaker or implantable medical device, abnormal connective tissue diseases, coagulopathy (PLT<100,000/μL, PT>14 seconds, APTT>36 seconds, INR>1.3), implants near or in the brain, or those deemed Unsuitable for this treatment by the physician; Patient under anticoagulants with coagulopathy (PLT<100,000/μL, PT>14 seconds, APTT>36 seconds, INR>1.3); Unable to cooperate with treatment or functional assessment due to impaired consciousness or aphasia; inability to informed consent; Patient with cranial bone factor causing the inability of tFUS penetration; Patients who are not suitable for undergoing CT imaging examination; Patients with severe or uncontrollable intracranial pressure; Patients requiring anticoagulants; Any intracranial space-occupying lesions; Significant calcification of intracranial vessels based on pre-treatment CT imaging; Subjects with lesions/wounds on the scalp in the target region.