Studying stress, diet and gut health in teens with obesity
Collects samples and questionnaires from adolescents aged 11 to 17 who are overweight or obese.
Plain-language title generated from the registry record
Registry title: The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
Key facts
- Where
- Antwerp, De Haan, Ghent, Ottignies-Louvain-la-Neuve, and Roeselare, BelgiumSee the 7 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 11 and 17 years old?
Source: NCT06391671, who can take part
Where in Belgium
- UZ AntwerpenAntwerp, BelgiumTaking people
- ZNA MiddelheimAntwerp, BelgiumTaking people
- ZeepreventoriumDe Haan, BelgiumTaking people
- AZ Jan Palfijn Gent, Oost-Vlaanderen, Belgium, 9000Ghent, BelgiumTaking people
- Ghent university hospitalGhent, BelgiumTaking people
- Clairs VallonsOttignies-Louvain-la-Neuve, BelgiumTaking people
- AZ DeltaRoeselare, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Ghent
- Trial code
- NCT06391671
- Record updated
- 30 April 2024
- Original description
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity.Read full original descriptionShow less
The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents (FAME)
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity.
The investigators will assess the following hypotheses:
* Weight condition is reflected by the fecal metabolome (WP1) * Emotional stress is implicated in weight condition (WP1) * Functionality of the gut microbiome is related to the diet-stress-obesity axis (WP2) * Dietary pattern impacts the fecal metabolome and gut microbiome (WP2) * Personalized dietary intervention outperforms generalized dietary approaches (WP3)
Participants will:
* Produce a saliva, stool and hair sample * Fill in questionnaires regarding mental health, medical health and demographic information * Fill in a food frequency questionnaire and a 24-hrecalls * Be measured (height, weight, fat% and waist circumference)
The samples will be analyzed using a technique called metabolomics to identify biomarker candidates with diagnostic and/or prognostic potential. Additionally, microbiome analysis will be performed to map the microbiome of all groups.
Inclusion: Age 11-17 years.
Exclusion: In treatment with systemic concentrations of corticosteroids (cortisone). Eg cortisone/betamethasone/Dexamethasone/Fludrocortisone/Hydrocortisone in pill form or administration by injections; Type 1 diabetes; Medical conditions including pancreatic failure; Developmental and hormonal disorders. E.g. thyroid problems, adrenal problems, Kallmann's syndrome, Klinefelter's syndrome, Prader-Willi syndrome (PWS), Congenital hypogonadotropic hypogonadism (CHH), ; Obesity/overweight; Pregnancy.