Studying stress, diet and gut health in teens with obesity
Collects samples and questionnaires from adolescents aged 11 to 17 who are overweight or obese.
Plain-language title generated from the registry record
Registry title: The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
Key facts
- Where
- Antwerp, De Haan, Ghent, Ottignies-Louvain-la-Neuve, and Roeselare, BelgiumSee the 7 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for teenagers aged 11 to 17 years. Participants give saliva, stool and hair samples, fill in questionnaires and have body measurements taken.
- Age
- 11 to 17 years
- Sex
- All sexes can join.
- Earlier treatment
- People in treatment with systemic corticosteroids (cortisone) in pill form or by injection cannot join.
Main reasons for not taking part
- Obesity or overweight
- Type 1 diabetes
- Medical conditions including pancreatic failure
- Developmental and hormonal disorders, such as thyroid or adrenal problems
- Pregnancy
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 11 and 17 years old?
Source: NCT06391671, who can take part
Where in Belgium
- UZ AntwerpenAntwerp, BelgiumTaking people
- ZNA MiddelheimAntwerp, BelgiumTaking people
- ZeepreventoriumDe Haan, BelgiumTaking people
- AZ Jan Palfijn Gent, Oost-Vlaanderen, Belgium, 9000Ghent, BelgiumTaking people
- Ghent university hospitalGhent, BelgiumTaking people
- Clairs VallonsOttignies-Louvain-la-Neuve, BelgiumTaking people
- AZ DeltaRoeselare, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Ghent
- Trial code
- NCT06391671
- Record updated
- 30 April 2024
- Original description
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity.Read full original descriptionShow less
The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents (FAME)
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity.
The investigators will assess the following hypotheses:
* Weight condition is reflected by the fecal metabolome (WP1) * Emotional stress is implicated in weight condition (WP1) * Functionality of the gut microbiome is related to the diet-stress-obesity axis (WP2) * Dietary pattern impacts the fecal metabolome and gut microbiome (WP2) * Personalized dietary intervention outperforms generalized dietary approaches (WP3)
Participants will:
* Produce a saliva, stool and hair sample * Fill in questionnaires regarding mental health, medical health and demographic information * Fill in a food frequency questionnaire and a 24-hrecalls * Be measured (height, weight, fat% and waist circumference)
The samples will be analyzed using a technique called metabolomics to identify biomarker candidates with diagnostic and/or prognostic potential. Additionally, microbiome analysis will be performed to map the microbiome of all groups.
Inclusion: Age 11-17 years.
Exclusion: In treatment with systemic concentrations of corticosteroids (cortisone). Eg cortisone/betamethasone/Dexamethasone/Fludrocortisone/Hydrocortisone in pill form or administration by injections; Type 1 diabetes; Medical conditions including pancreatic failure; Developmental and hormonal disorders. E.g. thyroid problems, adrenal problems, Kallmann's syndrome, Klinefelter's syndrome, Prader-Willi syndrome (PWS), Congenital hypogonadotropic hypogonadism (CHH), ; Obesity/overweight; Pregnancy.