Brain Imaging Study of Pseudobulbar Affect in ALS Patients
Uses brain imaging scans to study brain connections in people with ALS and pseudobulbar affect.
Plain-language title generated from the registry record
Registry title: Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
Key facts
- Where
- Aalborg, DenmarkSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT06396260, who can take part
Where in Denmark
- Aalborg University HospitalAalborg, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aalborg University Hospital
- Trial code
- NCT06396260
- Record updated
- 29 January 2025
- Original description
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).Read full original descriptionShow less
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).
Inclusion: Diagnosed with ALS in the last 6 months according to Gold Coast Criteria.
Exclusion: Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics; Ongoing treatment with any antidepressants or any antipsychotics at recruitment; Lesional neurological diseases, such as stroke, tumor or multiple sclerosis; Epilepsy; Neurodegenerative diseases other than ALS; Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia; Severe liver or kidney disease; Dysregulated heart disease; Diagnosed with frontotemporal dementia; - Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview; Lack of ability to cooperate; Pregnancy; Alcohol addiction defined as over 21 units weekly; Contraindication for MRI and MEG scan according to hospital guidelines.